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Genetics of atrial fibrillation: rare mutations, common polymorphisms, and clinical relevance.

作者信息

Darbar Dawood

机构信息

Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA.

出版信息

Heart Rhythm. 2008 Mar;5(3):483-6. doi: 10.1016/j.hrthm.2007.09.002. Epub 2007 Sep 18.

DOI:10.1016/j.hrthm.2007.09.002
PMID:18313611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2292402/
Abstract
摘要

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Genetics of atrial fibrillation: rare mutations, common polymorphisms, and clinical relevance.心房颤动的遗传学：罕见突变、常见多态性及临床相关性。
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Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.染色体 4q25 变异是与家族性心房颤动相关的罕见离子通道突变的遗传修饰因子。
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Atrial fibrillation: evidence for genetically determined disease.
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Genetics of lone atrial fibrillation.孤立性心房颤动的遗传学
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Is atrial fibrillation a genetic disease?心房颤动是一种遗传性疾病吗？
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[Genetic factors in the pathogenesis of atrial fibrillation].
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Potassium channel gene mutations rarely cause atrial fibrillation.钾通道基因突变很少导致心房颤动。
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Atrial Fibrillation Susceptibility Alleles on Chromosome 4q25 Modulate Response to Catheter Ablation.4q25染色体上的房颤易感性等位基因调节对导管消融的反应。
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Association of atrial fibrillation risk alleles and response to acute rate control therapy.心房颤动风险等位基因与急性心率控制治疗反应的关联
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Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients.心房颤动是危重症患者死亡的独立预测因素。
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Improved understanding of the pathophysiology of atrial fibrillation through the lens of discrete pathological pathways.通过离散病理途径更好地理解心房颤动的病理生理学。
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Genetic mechanisms of atrial fibrillation: impact on response to treatment.心房颤动的遗传机制：对治疗反应的影响。
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Dis Model Mech. 2013 Mar;6(2):332-41. doi: 10.1242/dmm.010488. Epub 2012 Dec 7.

本文引用的文献

1
Genomewide association analysis of coronary artery disease.冠状动脉疾病的全基因组关联分析。
N Engl J Med. 2007 Aug 2;357(5):443-53. doi: 10.1056/NEJMoa072366. Epub 2007 Jul 18.
2
Variants conferring risk of atrial fibrillation on chromosome 4q25.位于4号染色体q25区域的增加心房颤动风险的变异体。
Nature. 2007 Jul 19;448(7151):353-7. doi: 10.1038/nature06007. Epub 2007 Jul 1.
3
Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation.基因多态性调节孤立性心房颤动患者对抗心律失常药物治疗的症状性反应。
Heart Rhythm. 2007 Jun;4(6):743-9. doi: 10.1016/j.hrthm.2007.02.006. Epub 2007 Feb 9.
4
Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation?拉伸敏感的KCNQ1突变：房颤发病机制中遗传因素与环境因素之间的联系？
J Am Coll Cardiol. 2007 Feb 6;49(5):578-86. doi: 10.1016/j.jacc.2006.09.044. Epub 2007 Jan 22.
5
Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation.心房颤动中连接蛋白40基因（GJA5）的体细胞突变。
N Engl J Med. 2006 Jun 22;354(25):2677-88. doi: 10.1056/NEJMoa052800.
6
Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation.由于KCNA5功能丧失突变导致的Kv1.5通道病会引发人类房颤。
Hum Mol Genet. 2006 Jul 15;15(14):2185-91. doi: 10.1093/hmg/ddl143. Epub 2006 Jun 13.
7
Familial aggregation of atrial fibrillation in Iceland.冰岛房颤的家族聚集性。
Eur Heart J. 2006 Mar;27(6):708-12. doi: 10.1093/eurheartj/ehi727. Epub 2006 Jan 20.
8
Familial aggregation in lone atrial fibrillation.孤立性心房颤动的家族聚集性。
Hum Genet. 2005 Nov;118(2):179-84. doi: 10.1007/s00439-005-0034-8. Epub 2005 Nov 15.
9
Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization.心房颤动相关的minK38G/S多态性调节延迟整流电流和膜定位。
Cardiovasc Res. 2005 Aug 15;67(3):520-8. doi: 10.1016/j.cardiores.2005.03.007. Epub 2005 Apr 12.
10
Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.与心脏瓣膜病和心房颤动相关的人类心房离子通道及转运体亚基基因表达重塑
Circulation. 2005 Jul 26;112(4):471-81. doi: 10.1161/CIRCULATIONAHA.104.506857. Epub 2005 Jul 18.