Davidson Patrick S R, Anaki David, Ciaramelli Elisa, Cohn Melanie, Kim Alice S N, Murphy Kelly J, Troyer Angela K, Moscovitch Morris, Levine Brian
Rotman Research Institute, Baycrest Centre, Toronto, Canada.
Neuropsychologia. 2008;46(7):1743-55. doi: 10.1016/j.neuropsychologia.2008.01.011. Epub 2008 Feb 2.
Although neuroimaging and human lesion studies agree that the medial parietal region plays a critical role in episodic memory, many neuroimaging studies have also implicated lateral parietal cortex, leading some researchers to suggest that the lateral region plays a heretofore underappreciated role in episodic memory. Because there are very few extant lesion data on this matter, we examined memory in six cases of focal lateral parietal damage, using both clinical and experimental measures, in which we distinguished between recollection and familiarity. The patients did not have amnesia, but they did show evidence of disrupted recollection on an anterograde memory task. Although the exact mechanisms remain to be elucidated, lateral parietal damage appears to impair some aspects of episodic memory.
尽管神经影像学和人类损伤研究一致认为内侧顶叶区域在情景记忆中起关键作用，但许多神经影像学研究也表明外侧顶叶皮层也与之相关，这使得一些研究人员认为外侧区域在情景记忆中发挥着迄今未被充分认识的作用。由于关于这一问题现存的损伤数据非常少，我们使用临床和实验方法，对6例局灶性外侧顶叶损伤患者的记忆进行了研究，其中我们区分了回忆和熟悉度。这些患者没有失忆，但在顺行性记忆任务中确实表现出回忆受损的迹象。尽管确切机制仍有待阐明，但外侧顶叶损伤似乎会损害情景记忆的某些方面。
