Surdell Daniel L, Bernstein Richard A, Hage Ziad A, Batjer H Hunt, Bendok Bernard R
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Surg Neurol. 2009 May;71(5):604-9. doi: 10.1016/j.surneu.2007.11.021. Epub 2008 Mar 3.
Although extracranial carotid dissection with stroke is common, intracranial dissection with stroke is rare. Stenting has been used to treat extracranial carotid dissections. Intracranially, however, it is only recently that stents have become a feasible option for this disease. We present a case of a spontaneous intracranial CAD with progressive symptoms despite medical management treated with a self-expanding intracranial micronitinol stent.
A 47-year-old, right-handed woman presented to the emergency department after noticing left-sided face and arm weakness and numbness, along with slurred speech. The patient was started on aspirin 325 mg/d orally and lovenox 40 mg/d subcutaneously. On hospital day 2, the patient was noted to have repeated episodes of weakness and numbness on the left side and MRI evidence of a new stroke. A diagnostic cerebral angiogram from a selective right internal carotid injection revealed a flow-limiting stenosis secondary to a dissection of the supraclinoid internal carotid artery with severe flow limitation to the hemisphere. Endovascular management was decided on, and a Neuroform stent measuring 4.5 x 20 mm (Boston Scientific Corporation, Natick, Mass) was deployed across the dissection with significant improvement of flow to that hemisphere on the poststent angiogram.
This case illustrates the successful off-label use of a self-expanding intracranial nitinol stent to treat a symptomatic intracranial internal CAD in the setting of failure of traditional medical management. This is a promising application of novel endovascular technology.
虽然伴有卒中的颅外颈动脉夹层很常见,但伴有卒中的颅内夹层却很罕见。支架置入术已被用于治疗颅外颈动脉夹层。然而,在颅内,直到最近支架才成为治疗这种疾病的一种可行选择。我们报告一例自发性颅内颈动脉夹层病例,尽管采用了药物治疗,但症状仍持续进展,最终使用自膨式颅内镍钛诺支架进行了治疗。
一名47岁右利手女性,在出现左侧面部和手臂无力、麻木以及言语含糊不清后就诊于急诊科。患者开始口服阿司匹林325mg/d,皮下注射低分子肝素40mg/d。住院第2天,患者左侧反复出现无力和麻木发作,MRI显示有新的卒中证据。选择性右侧颈内动脉造影显示,鞍上颈内动脉夹层导致血流受限性狭窄,该半球血流严重受限。决定进行血管内治疗,置入一枚4.5×20mm的Neuroform支架(波士顿科学公司,马萨诸塞州纳蒂克)跨越夹层,支架置入术后血管造影显示该半球血流有显著改善。
本病例说明了在传统药物治疗失败的情况下,成功地将自膨式颅内镍钛诺支架用于治疗有症状的颅内颈内动脉夹层。这是新型血管内技术的一个有前景的应用。