Matesanz Fuencisla, Fernández Oscar, Milne Roger L, Fedetz Maria, Leyva Laura, Guerrero Miguel, Delgado Concepción, Lucas Miguel, Izquierdo Guillermo, Alcina Antonio
Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain.
J Neuroimmunol. 2008 Mar;195(1-2):146-50. doi: 10.1016/j.jneuroim.2008.01.004. Epub 2008 Mar 3.
Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case-control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r(2) = 0.87), differed between MS cases and controls. The C allele of FCRL3_3 was found to be protective for MS (per allele OR = 0.81, 95% C.I. = 0.70-0.94; P-value = 0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3.
Fc受体样家族成员FCRL3基因的某些多态性与多种自身免疫性疾病相关，最近还与多发性硬化症（MS）有关。我们对来自西班牙南部的645例MS患者和786名对照（均为白种人）进行了FCRL3基因中三个单核苷酸多态性（SNP）的病例对照研究。处于高度连锁不平衡状态（r(2) = 0.87）的两个SNP（rs7528684/FCRL3_3和rs7522061/N28D）的基因型和等位基因频率在MS病例和对照之间存在差异。发现FCRL3_3的C等位基因对MS具有保护作用（每个等位基因的优势比OR = 0.81，95%置信区间C.I. = 0.70 - 0.94；P值 = 0.007），N28D的G变体也是如此，但未发现rs11264799/FCRL3_4存在关联。单倍型分析证实了这些关联，对于携带FCRL3_3的C等位基因的单倍型，效应大小高度一致
