Viola Réka, Benko Ria, Nagy Gábor, Soós Gyöngyvér
Department of Clinical Pharmacy, University of Szeged, Hungary.
Pharmacoepidemiol Drug Saf. 2008 Apr;17(4):401-5. doi: 10.1002/pds.1574.
The aim of this study was to analyse the changes in the amount and structure of Hungarian antidepressant consumption at national and regional level, furthermore to investigate the possible relationship between antidepressant sales and trends in suicide rates using regional data.
Retrospective analysis of antidepressant sales data was performed on a 12 years period (1993-2004), applying the ATC/DDD methodology developed by WHO. Linear regression model was set up to investigate the trends in antidepressant utilisation. The association between antidepressant consumption and suicide rates was measured by Pearson correlation.
The nationwide utilisation of antidepressants revealed more than five-fold increase in the studied 12 year period. The usage of tricyclic antidepressants (N06AA) decreased to one third of the previous value, while the usage of selective serotonin reuptake inhibitors (N06AB) multiplied by 21. The consumption of 'other antidepressants' (N06AX) was found very low (3.66 DDD/1000 inhabitants/day in 2004). There was not found any significant correlation between increased antidepressant consumption and decreased suicide rates at regional level by our statistical analysis (r (min) = -0.160; r (max) = -0.314).
Further investigation is required to identify determinants that have contributed to recent decline in suicide rate in Hungary.
本研究旨在分析匈牙利全国及地区层面抗抑郁药物消费数量和结构的变化，此外，利用地区数据调查抗抑郁药物销售与自杀率趋势之间的可能关系。
采用世界卫生组织制定的ATC/DDD方法，对12年期间（1993 - 2004年）的抗抑郁药物销售数据进行回顾性分析。建立线性回归模型以研究抗抑郁药物使用趋势。通过Pearson相关性分析衡量抗抑郁药物消费与自杀率之间的关联。
在研究的12年期间，全国范围内抗抑郁药物的使用量增长了五倍多。三环类抗抑郁药（N06AA）的使用量降至先前值的三分之一，而选择性5-羟色胺再摄取抑制剂（N06AB）的使用量增长了21倍。发现“其他抗抑郁药”（N06AX）的消费量非常低（2004年为3.66限定日剂量/1000居民/天）。通过我们的统计分析，在地区层面未发现抗抑郁药物消费增加与自杀率下降之间存在任何显著相关性（r（最小值）= -0.160；r（最大值）= -0.314）。
需要进一步调查以确定导致匈牙利近期自杀率下降的决定因素。
