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用于医学应用的多电荷碳离子产生。

Multiply charged carbon-ion production for medical application.

作者信息

Kitagawa A, Muramatsu M, Sasaki N, Takasugi W, Wakaisami S, Biri S, Drentje A G

机构信息

National Institute of Radiological Sciences, Inage, Chiba, Japan.

出版信息

Rev Sci Instrum. 2008 Feb;79(2 Pt 2):02C303. doi: 10.1063/1.2832361.

Abstract

Over 3000 cancer patients have already been treated by the heavy-ion medical accelerator in Chiba at the National Institute of Radiological Sciences since 1994. The clinical results have clearly verified the effectiveness and safety of heavy-ion radiotherapy. The most important result has been to establish that the carbon ion is one of the most effective radiations for radiotherapy. The ion source is required to realize a stable beam with the same conditions for daily operation. However, the deposition of carbon ions on the wall of the plasma chamber is normally unavoidable. This causes an "anti-wall-coating effect," i.e., a decreasing of the beam, especially for the higher charge-state ions due to the surface material of the wall. The ion source must be required to produce a sufficiently intense beam under the bad condition. Other problems were solved by improvements and maintenance, and thus we obtained enough reproducibility and stability along with decreased failures. We summarize our over 13 years of experience, and show the scope for further developments.

摘要

自1994年以来,位于千叶的日本国立放射科学研究所的重离子医用加速器已经治疗了3000多名癌症患者。临床结果已明确证实了重离子放射治疗的有效性和安全性。最重要的成果是确定碳离子是放射治疗中最有效的辐射之一。为了在日常运行中以相同条件实现稳定束流,需要离子源。然而,碳离子在等离子体腔室壁上的沉积通常是不可避免的。这会导致“反壁涂层效应”,即束流减少,特别是对于由于壁面材料导致的高电荷态离子。必须要求离子源在恶劣条件下产生足够强的束流。通过改进和维护解决了其他问题,因此我们获得了足够的重现性和稳定性,同时减少了故障。我们总结了我们13年多的经验,并展示了进一步发展的空间。

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