Reznik R B
Department of Community Medicine, Royal Prince Alfred Hospital, Queen Elizabeth II Rehabilitation Centre, Camperdown, NSW.
Med J Aust. 1991 Aug 5;155(3):153-6. doi: 10.5694/j.1326-5377.1991.tb142180.x.
OBJECTIVE; To review the effectiveness of a hepatitis B vaccination programme for high risk infants within a mobile urban population.
A follow-up study of 1429 infants enrolled consecutively in the programme from September 1987 to December 1988.
The programme was established in early childhood centres within inner metropolitan Sydney, an area where 30% of residents were born in non-English speaking countries and where doubts had previously been expressed about the efficacy of vaccination.
Neonates born to mothers who were surface antigen positive, born in selected countries with a 5% prevalence of surface antigen carriage, Aboriginal or intravenous drug users.
Documented vaccination given by early childhood centre nurses. Some adjustment was made for parents' reports of vaccination given elsewhere.
Two vaccinations were given to 87% and three to 73% of these infants. If we include vaccinations apparently given elsewhere we estimate that 92% may have been fully protected.
The programme produced high rates of compliance with vaccinations within a population where the delivery of such a service was thought to be difficult. Experience with the current State policy for hepatitis B vaccination indicates that it may not optimally reduce the pool of surface antigen carriers within our community.
目的；回顾一项针对城市流动高危婴儿的乙肝疫苗接种计划的有效性。
对1987年9月至1988年12月连续纳入该计划的1429名婴儿进行随访研究。
该计划在悉尼市中心的幼儿中心设立，该地区30%的居民出生于非英语国家，此前曾有人对疫苗接种的效果表示怀疑。
母亲为表面抗原阳性的新生儿、出生于表面抗原携带率达5%的特定国家的新生儿、原住民或静脉吸毒者。
幼儿中心护士记录的疫苗接种情况。对家长报告的在其他地方接种的情况做了一些调整。
这些婴儿中，87%接种了两剂疫苗，73%接种了三剂疫苗。如果把显然在其他地方接种的疫苗算在内，我们估计92%的婴儿可能得到了充分保护。
在被认为难以提供此类服务的人群中，该计划实现了很高的疫苗接种率。当前州级乙肝疫苗接种政策的经验表明，它可能无法最有效地减少我们社区表面抗原携带者的数量。
