Adler G
Neurologische Universitätsklinik Göttingen, Federal Republic of Germany.
Eur Arch Psychiatry Clin Neurosci. 1991;240(6):367-9. doi: 10.1007/BF02279768.
Controlled hyperventilation (HV) may be used as an experimental procedure to produce transient ischaemic hypoxia of the brain. The effect of HV on the cortical auditory evoked potential (AEP) components N1 and P2 was studied in ten healthy adult subjects. AEP were recorded before HV, during 3 min of controlled HV, and 1 min and 5 min after the end of HV. The P2 amplitude was significantly reduced by HV and regained its initial value 1 min after the end of HV. The P2 amplitude decrease probably reflects an impairment of synaptic function produced by cerebral hypoxia. Thus, the investigation of cortical AEP components may provide a useful parameter in the study of anti-ischaemic or anti-hypoxic therapies.
控制性过度通气（HV）可作为一种实验手段，用于引发大脑短暂性缺血性缺氧。本研究在10名健康成年受试者中，探究了HV对皮质听觉诱发电位（AEP）的N1和P2成分的影响。在HV前、控制性HV的3分钟期间、HV结束后的1分钟和5分钟记录AEP。HV使P2波幅显著降低，并在HV结束1分钟后恢复至初始值。P2波幅降低可能反映了脑缺氧导致的突触功能损害。因此，对皮质AEP成分的研究可能为抗缺血或抗缺氧治疗的研究提供一个有用的参数。
