Oh Eun-Jee, Jekarl Dong Wook, Jang Hyun-Sik, Park Hae-Il, Park Yeon-Joon, Choi Hyun Ah, Chun Chung-Sik, Kim Yonggoo, Kim Hyung Hoi
Department of Laboratory Medicine, College of Medicine, Catholic University of Korea, 505 Banpo-dong Seocho-ku, Seoul, 137-040, South Korea.
Ann Clin Lab Sci. 2008 Winter;38(1):80-2.
The Di(b) antigen usually occurs with high incidence, except in certain Asian and South American Indian populations. In general, hemolysis caused by anti-Di(b) is not severe and its clinical course is benign. We report a Korean neonate with severe hemolytic disease of the newborn caused by anti-Di(b). The phenotype and genotype of the Diego blood group system of the patient and his mother were Di(a+b+) and Di(a+b-), respectively. The mother's serum and eluate from the neonate's erythrocytes contained anti-Di(b). This case was successfully managed with phototherapy and high dose iv immunoglobulin. Since most commercial antibody detection panels do not contain Di(b-) red cells, it is important to consider anti-Di(b) in cases of hemolytic disease of the newborn caused by an antibody against a high frequency antigen.
Di(b)抗原通常具有较高的发生率，但在某些亚洲和南美印第安人群体中除外。一般来说，抗Di(b)引起的溶血并不严重，其临床过程是良性的。我们报告了一例由抗Di(b)引起的韩国新生儿严重溶血病。患者及其母亲的迭戈血型系统的表型和基因型分别为Di(a+b+)和Di(a+b-)。母亲的血清和新生儿红细胞洗脱液中含有抗Di(b)。该病例通过光疗和大剂量静脉注射免疫球蛋白成功治疗。由于大多数商业抗体检测板不含Di(b-)红细胞，因此在由针对高频抗原的抗体引起的新生儿溶血病病例中考虑抗Di(b)很重要。
