Lin Mingchun, Liu Meixiu, Zhang Shulian, Chen Chao, Wang Jin
Neonatal Department, Children's Hospital of Fudan University, Shanghai, 201102, People's Republic of China.
Neonatal Fellowship Training at Children's Hospital of Fudan University, Yueqing Maternal and Child Health Hospital, Wenzhou, Zhejiang Province, People's Republic of China.
J Blood Med. 2021 Jun 25;12:497-504. doi: 10.2147/JBM.S303633. eCollection 2021.
To review the neonatal cases with different types of minor blood group incompatible haemolytic diseases in China, and to improve the clinical understanding and management.
Seven cases from January, 1st, 2013 to December 31st, 2019 were searched out and reviewed retrospectively. All clinical data and laboratory findings were collected.
There were totally seven cases enrolled including three cases of MNS, three of Diego, and one of Kidd combined with Rh, anti-RhE incompatibility. Among the seven cases, two had intrauterine transfusion, two underwent exchange transfusion, five received intravenous immune globulin, five cases developed anaemia, and three of them had transfusion. But among them, only four were found to have positive antibody screening and three were confirmed HDN with antibody types antenatally.
The clinical presentation is diverse. Antibody screening followed by the technique of peak systolic velocity in the fetal middle cerebral artery (MCA-PSV) helps to filter out the severe cases.
回顾中国不同类型的小血型不合溶血病新生儿病例，以提高临床认识和管理水平。
检索出2013年1月1日至2019年12月31日期间的7例病例并进行回顾性分析。收集所有临床资料和实验室检查结果。
共纳入7例病例，其中MNS血型不合3例，迭戈血型不合3例，基德血型与Rh血型联合、抗-RhE血型不合1例。7例中，2例行宫内输血，2例行换血治疗，5例接受静脉注射免疫球蛋白，5例发生贫血，其中3例接受输血治疗。但其中仅4例抗体筛查阳性，3例产前经抗体类型确诊为新生儿溶血病。
临床表现多样。抗体筛查结合胎儿大脑中动脉收缩期峰值流速（MCA-PSV）技术有助于筛选出重症病例。
