[降压因子对正常血压和自发性高血压大鼠动脉平滑肌细胞钙离子内流的影响]
[Effect of antihypertensive factor on Ca2+ influx in arterial smooth muscle from normotensive and spontaneously hypertensive rats].
作者信息
Wen Y Y
机构信息
Institute of Basic Medical Sciences, Beijing.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1991 Apr;13(2):129-32.
Aorta segments (A) and mesenteric arteries (MA) from stroke prone spontaneously hypertensive rats (SHRsp) and control Wistar Kyoto rats (WKY) were used in the present study to assess the effect of AHF on Ca2+ influx in vascular smooth muscle (VSM). The results indicated that Ca2+ influx in VSM of SHRsp was much higher than that of WKY rats (P less than 0.05). AHF at 10(-7), 10(-6) and 10(-5) g/ml can significantly inhibit Ca2+ influx in a dose-dependent manner in VSM of both A and MA (P less than 0.05 and less than 0.01). The suppression effect of AHF on Ca2+ influx and the concentration-dependent relationship were more obvious in MA than in A. The Ca2+ influx in VSM of WKY rats was unaffected by administration of AHF.
在本研究中，使用了来自易中风自发性高血压大鼠（SHRsp）和对照Wistar Kyoto大鼠（WKY）的主动脉段（A）和肠系膜动脉（MA），以评估抗高血压因子（AHF）对血管平滑肌（VSM）中Ca2+内流的影响。结果表明，SHRsp的VSM中Ca2+内流远高于WKY大鼠（P<0.05）。10^(-7)、10^(-6)和10^(-5) g/ml的AHF可显著抑制A和MA的VSM中Ca2+内流，呈剂量依赖性（P<0.05和<0.01）。AHF对Ca2+内流的抑制作用及其浓度依赖性关系在MA中比在A中更明显。给予AHF对WKY大鼠VSM中的Ca2+内流没有影响。
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