自发性高血压大鼠红细胞降压因子对大鼠血压及动脉平滑肌Ca2+内流的影响
Effects of antihypertensive factor from erythrocyte of spontaneously hypertensive rats on the blood pressure and Ca2+ influx of arterial smooth muscle in rats.
作者信息
Wen Y Y, Chen M Q, Jia H P, Wu G Y, Zhou L P, Lu T, Zhang S F
机构信息
Department of Physiology, Chinese Academy of Medical Sciences, Beijing.
出版信息
Chin Med J (Engl). 1991 May;104(5):376-80.
The effects of a partially purified antihypertensive factor (AHF) from erythrocytes of spontaneously hypertensive rats (SHR) on the blood pressure (BP) and Ca2+ influx of vascular smooth muscle (VSM) in rats were studied. The results indicated that AHF could produce a marked prolonged depressor effect and significantly inhibit the Ca2+ influx dose-dependently on both SHR and renal hypertensive rat (RHR) either in acute or in chronic experiments, but not on normotensive rats. It suggested that the inhibition of Ca2+ influx might be one of the important mechanisms for AHF as an endogenous depressor substance.
研究了从自发性高血压大鼠（SHR）红细胞中提取的部分纯化的抗高血压因子（AHF）对大鼠血压（BP）和血管平滑肌（VSM）钙内流的影响。结果表明，无论是急性实验还是慢性实验，AHF均可产生显著且持久的降压作用，并能剂量依赖性地显著抑制SHR和肾性高血压大鼠（RHR）的钙内流，但对正常血压大鼠无此作用。这表明抑制钙内流可能是AHF作为内源性降压物质的重要机制之一。
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