Kostovski E, Iversen P O, Birkeland K, Torjesen P A, Hjeltnes N
Section for Spinal Cord Injury, Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway.
Spinal Cord. 2008 Aug;46(8):559-64. doi: 10.1038/sc.2008.3. Epub 2008 Mar 4.
Blood samples were frequently collected during a 24-h period from six tetraplegic men. The results were compared with those of eight able-bodied controls.
Previous studies have reported conflicting results regarding the plasma concentrations of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in tetraplegia. The objective of this study was to examine the pituitary-gonadal axis by determining the plasma concentrations and circadian variations of these hormones in men with long-standing tetraplegia.
Sunnaas Hospital, Norway.
The plasma concentrations of hormones were measured with standardized assays.
All three hormones and free testosterone index were decreased in the tetraplegic subjects compared with the able-bodied controls (P<0.05). We also determined the morning levels of hormones with regulatory effects on testosterone, LH and FSH. Whereas plasma leptin was significantly higher in the tetraplegic group, no significant differences in the morning plasma values for insulin, SHBG, GH or IGF-1, or in the 24-h urine concentrations of cortisol were detected between the two groups. The plasma concentration of LH displayed a circadian variation (P<0.05) in the tetraplegic group, but not among the able-bodied. No circadian variation was noted for the plasma concentrations of testosterone and FSH in either group.
Our data indicate that, over time, tetraplegic male subjects might be at risk of developing hypogonadism.
在24小时内，对6名四肢瘫痪男性频繁采集血样。将结果与8名身体健全的对照者的结果进行比较。
先前的研究报告了关于四肢瘫痪患者睾酮、促黄体生成素（LH）和促卵泡生成素（FSH）血浆浓度的相互矛盾的结果。本研究的目的是通过测定长期四肢瘫痪男性这些激素的血浆浓度和昼夜变化来检查垂体-性腺轴。
挪威松纳斯医院。
用标准化检测方法测量激素的血浆浓度。
与身体健全的对照者相比，四肢瘫痪受试者的所有三种激素和游离睾酮指数均降低（P<0.05）。我们还测定了对睾酮、LH和FSH有调节作用的激素的早晨水平。四肢瘫痪组的血浆瘦素显著更高，但两组之间在胰岛素、性激素结合球蛋白（SHBG）、生长激素（GH）或胰岛素样生长因子-1（IGF-1）的早晨血浆值，或皮质醇的24小时尿浓度方面未检测到显著差异。四肢瘫痪组中LH的血浆浓度呈现昼夜变化（P<0.05），而身体健全者中则没有。两组中睾酮和FSH的血浆浓度均未观察到昼夜变化。
我们的数据表明，随着时间的推移，四肢瘫痪男性受试者可能有发生性腺功能减退的风险。
