氯吡格雷过敏的快速口服脱敏程序。
Rapid oral desensitisation procedure in clopidogrel hypersensitivity.
机构信息
Department of Cardiology, Spaarne Hospital, Hoofddorp, the Netherlands.
出版信息
Neth Heart J. 2008;16(1):21-3. doi: 10.1007/BF03086112.
Abstract
We describe a patient who developed generalised pruritus with oedema and rash two weeks after she had started taking clopidogrel following coronary stent implantation. In the absence of other likely causative agents, clopidogrel hypersensitivity was probable. She was treated with a rapid oral desensitisation procedure, after which a daily dose of 75 mg clopidogrel was well tolerated. No major adverse events occurred during a follow-up period of eight months. Oral desensitisation in clopidogrel hypersensitivity seems to be a safe method to reduce the risk of coronary stent thrombosis. (Neth Heart J 2008;16:21-3.).
摘要
我们描述了一位患者，她在冠状动脉支架植入术后开始服用氯吡格雷两周后出现全身性瘙痒、水肿和皮疹。在没有其他可能的致病因素的情况下，氯吡格雷过敏的可能性较大。我们对她进行了快速口服脱敏治疗，此后她每日耐受 75 毫克氯吡格雷。在 8 个月的随访期间，未发生重大不良事件。氯吡格雷过敏的口服脱敏似乎是一种降低冠状动脉支架血栓形成风险的安全方法。（Neth Heart J 2008;16:21-3.）
相似文献
1
Rapid oral desensitisation procedure in clopidogrel hypersensitivity.氯吡格雷过敏的快速口服脱敏程序。
Neth Heart J. 2008;16(1):21-3. doi: 10.1007/BF03086112.
2
Aspirin desensitisation for Chinese patients with coronary artery disease.阿司匹林脱敏治疗中国冠心病患者。
Hong Kong Med J. 2013 Jun;19(3):207-13. doi: 10.12809/hkmj133914. Epub 2013 May 6.
3
Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.氯吡格雷与阿司匹林联用对比噻氯匹定与阿司匹林联用在预防冠状动脉支架植入术后支架内血栓形成方面的有效性。
Circulation. 1999 May 11;99(18):2364-6. doi: 10.1161/01.cir.99.18.2364.
4
Clopidogrel desensitization: case report and review of published protocols.氯吡格雷脱敏治疗：病例报告及已发表方案综述
Pharmacotherapy. 2008 Feb;28(2):259-70. doi: 10.1592/phco.28.2.259.
5
Combination therapy with clopidogrel and aspirin after coronary stenting.冠状动脉支架置入术后氯吡格雷与阿司匹林联合治疗。
Catheter Cardiovasc Interv. 2000 Jul;50(3):276-9. doi: 10.1002/1522-726x(200007)50:3<276::aid-ccd2>3.0.co;2-p.
6
Clopidogrel hypersensitivity: a novel multi-day outpatient oral desensitization regimen.氯吡格雷超敏反应：一种新的多日门诊口服脱敏方案。
Ann Pharmacother. 2010 Jan;44(1):11-8. doi: 10.1345/aph.1M379. Epub 2009 Dec 15.
7
Rash with both clopidogrel and ticlopidine in two patients following percutaneous coronary intervention with drug-eluting stents.两名患者在接受药物洗脱支架经皮冠状动脉介入治疗后，同时出现氯吡格雷和噻氯匹定引起的皮疹。
Ann Pharmacother. 2006 Jun;40(6):1204-7. doi: 10.1345/aph.1G587. Epub 2006 May 9.
8
Randomized comparison of ticlopidine and clopidogrel after intracoronary stent implantation in a broad patient population.在广泛患者群体中进行冠状动脉支架植入术后噻氯匹定与氯吡格雷的随机对照研究。
Circulation. 2001 Jul 31;104(5):539-43. doi: 10.1161/hc3001.093435.
9
Oral antiplatelet agent hypersensitivity and cross-reactivity managed by successful desensitisation.通过成功脱敏管理口服抗血小板药物超敏反应和交叉反应。
Asia Pac Allergy. 2015 Jan;5(1):51-4. doi: 10.5415/apallergy.2015.5.1.51. Epub 2015 Jan 28.
10
Management of clopidogrel hypersensitivity without drug interruption.不中断药物治疗情况下氯吡格雷超敏反应的管理。
Am J Cardiol. 2011 Mar 15;107(6):812-6. doi: 10.1016/j.amjcard.2010.11.002. Epub 2011 Jan 19.
引用本文的文献
1
Management Strategies for Clopidogrel Hypersensitivity.氯吡格雷过敏的管理策略。
Drugs. 2015 Jun;75(9):999-1007. doi: 10.1007/s40265-015-0414-x.
本文引用的文献
1
Antiplatelet therapy in patients undergoing coronary stenting: The risk of late stent thrombosis.接受冠状动脉支架置入术患者的抗血小板治疗：晚期支架血栓形成风险
Neth Heart J. 2006 Sep;14(9):297-300.
2
Desensitization for the management of clopidogrel hypersensitivity: initial clinical experience.
J Invasive Cardiol. 2006 Jul;18(7):341-4.
3
Clopidogrel desensitization.氯吡格雷脱敏疗法。
Ann Allergy Asthma Immunol. 2006 May;96(5):756-7. doi: 10.1016/S1081-1206(10)61080-0.
4
[Thrombosis of a coronary stent after discontinuing treatment with clopidogrel].停用氯吡格雷治疗后冠状动脉支架血栓形成
Ned Tijdschr Geneeskd. 2006 Apr 15;150(15):863-8.
5
Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia.伴有皮疹、发热和中性粒细胞减少的氯吡格雷超敏综合征。
Mayo Clin Proc. 2005 Oct;80(10):1368-70. doi: 10.4065/80.10.1368.
6
Clopidogrel-induced hypersensitivity syndrome associated with febrile pancytopenia.氯吡格雷诱导的超敏反应综合征伴发热性全血细胞减少症。
Int J Dermatol. 2005 Oct;44(10):882-4. doi: 10.1111/j.1365-4632.2005.02366b.x.
7
Clopidogrel (Plavix) desensitization: a case series.氯吡格雷（波立维）脱敏治疗：病例系列
Catheter Cardiovasc Interv. 2005 Aug;65(4):525-7. doi: 10.1002/ccd.20433.
8
Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation.裸金属支架、西罗莫司支架或紫杉醇支架植入后血栓性支架闭塞的30天发生率及6个月临床结局
J Am Coll Cardiol. 2005 Mar 15;45(6):947-53. doi: 10.1016/j.jacc.2004.09.079.
9
Rapid desensitization procedure for patients with aspirin hypersensitivity undergoing coronary stenting.对阿司匹林过敏的患者进行冠状动脉支架置入术时的快速脱敏程序。
Am J Cardiol. 2005 Feb 15;95(4):509-10. doi: 10.1016/j.amjcard.2004.10.022.
10
Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy.停用抗血小板治疗后药物洗脱冠状动脉支架的晚期血栓形成。
Lancet. 2004;364(9444):1519-21. doi: 10.1016/S0140-6736(04)17275-9.
Zotero 插件