Department of Cardiology, Spaarne Hospital, Hoofddorp, the Netherlands.
Neth Heart J. 2008;16(1):21-3. doi: 10.1007/BF03086112.
We describe a patient who developed generalised pruritus with oedema and rash two weeks after she had started taking clopidogrel following coronary stent implantation. In the absence of other likely causative agents, clopidogrel hypersensitivity was probable. She was treated with a rapid oral desensitisation procedure, after which a daily dose of 75 mg clopidogrel was well tolerated. No major adverse events occurred during a follow-up period of eight months. Oral desensitisation in clopidogrel hypersensitivity seems to be a safe method to reduce the risk of coronary stent thrombosis. (Neth Heart J 2008;16:21-3.).
我们描述了一位患者，她在冠状动脉支架植入术后开始服用氯吡格雷两周后出现全身性瘙痒、水肿和皮疹。在没有其他可能的致病因素的情况下，氯吡格雷过敏的可能性较大。我们对她进行了快速口服脱敏治疗，此后她每日耐受 75 毫克氯吡格雷。在 8 个月的随访期间，未发生重大不良事件。氯吡格雷过敏的口服脱敏似乎是一种降低冠状动脉支架血栓形成风险的安全方法。（Neth Heart J 2008;16:21-3.）
