Doogue Matthew P, Begg Evan J, Bridgman Paul
Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand.
Mayo Clin Proc. 2005 Oct;80(10):1368-70. doi: 10.4065/80.10.1368.
We report a case of a severe hypersensitivity syndrome reaction to clopidogrel that resolved with dechallenge and recurred on rechallenge. The reaction included neutropenia, rash, fever, tachycardia, nausea, and vomiting. This presentation is very similar to the frequently reported hypersensitivity syndrome reactions to the structurally similar drug ticlopidine and is very similar to a case involving clopidogrel reported previously in this Journal. We could find no other reports of similar cases related to clopidogrel.
我们报告了1例对氯吡格雷发生严重超敏反应综合征的病例，该反应在撤药后缓解，并在再次用药时复发。反应包括中性粒细胞减少、皮疹、发热、心动过速、恶心和呕吐。此表现与经常报道的对结构相似药物噻氯匹定的超敏反应综合征非常相似，也与本刊先前报道的1例氯吡格雷相关病例非常相似。我们未发现其他与氯吡格雷相关的类似病例报告。
