Correa-Araujo R, Oliveira J S, Ricciardi Cruz A
Department of Pathology, Faculty of Medicine of Triangulo Mineiro, Uberaba, State of Minas Gerais, Brazil.
Int J Cardiol. 1991 Jun;31(3):329-36. doi: 10.1016/0167-5273(91)90384-2.
Extraction and measurement of biogenic amines (norepinephrine, dopamine, serotonin and histamine) were carried out on human ventricular myocardium obtained from autopsies of individuals divided in the three following groups: chronic Chagas' heart disease (with congestive heart failure: 16 cases, and with sudden and unexpected death: 13 cases); hypertensive heart disease (12 cases); and control patients (with no heart disease: 12 cases). The myocardial samples were obtained from the free walls of left and right ventricles and from the apex. A significant depletion of norepinephrine was detected in those with congestive failure. A poorly elevated level of dopamine was also seen in right ventricular and apical myocardium from those with failure. Left ventricular and apical concentration of serotonin were significantly elevated in the presence of hypertensive heart disease. The most important findings were obtained with histamine, which is increased in both groups of Chagasic patients. We believe that the approach here reported may provide useful informations on the pathogenetic mechanisms, thus far poorly understood, of chronic Chagas' heart disease.
对取自三组个体尸检的人心室心肌进行了生物胺（去甲肾上腺素、多巴胺、5-羟色胺和组胺）的提取和测量：慢性恰加斯心脏病（伴有充血性心力衰竭：16例，以及猝死：13例）；高血压心脏病（12例）；以及对照患者（无心脏病：12例）。心肌样本取自左、右心室游离壁和心尖。在充血性心力衰竭患者中检测到去甲肾上腺素显著减少。在心力衰竭患者的右心室和心尖心肌中也可见多巴胺水平略有升高。高血压心脏病患者左心室和心尖的5-羟色胺浓度显著升高。关于组胺的发现最为重要，在两组恰加斯病患者中组胺均增加。我们认为，此处报道的方法可能会为慢性恰加斯心脏病迄今仍了解甚少的发病机制提供有用信息。
