Fajolu I B, Grange O A, Renner J K, Odunukwe N W, Njokanma O F, Ahmed O A, Efenemokwu C
General Hospital Isolo.
Nig Q J Hosp Med. 2007 Jul-Sep;17(3):97-100. doi: 10.4314/nqjhm.v17i3.12553.
Iron deficiency is the commonest cause of nutritional anaemia in children worldwide particularly in developing countries. Infants and toddlers are prone to developing iron deficiency anaemia (IDA). This study was carried out to determine the prevalence of IDA and some factors associated with it in this group of children.
Haemoglobin concentration and mean corpuscular volume (MCV) estimations carried out in 282 apparently well children aged 6-24 months. Estimations of serum iron (SI), total iron binding capacity (TIBC), serum ferritin (SF) and transferrin saturation (TS) were also determined in children with anaemia (Hb concentration < 11.0 g/dl). Information on current diet was also obtained using a diet record.
Two hundred and twenty three (79.1%) children had anaemia. The mean Hb concentrations of all the age groups were less than 11.0 g/dl. Forty (14.9%) children had IDA (defined as aneamia plus 2 or more of the following--MCV < 70fl, Ts < 10% or SF < 10 microg/dL). The mean age of children with IDA (8.96 +/- 2.54 months) was statistically lower than for those without the condition 10.94 +/- 4.55 months (p = 0.016). Inclusion of vegetables and animal protein less than three times a week in the diet were both significantly associated with IDA.
The prevalence of IDA in this study is high especially before the age of 12 months and an average weekly intake less than 3 times a week or iron rich foods like animal protein and vegetables was significantly associated with IDA. Emphasis should be on the inclusion of iron rich foods in the diet following exclusive breastfeeding to reduce the prevalence of IDA in these children.
缺铁是全球儿童营养性贫血最常见的原因,在发展中国家尤为如此。婴幼儿容易患缺铁性贫血(IDA)。本研究旨在确定这组儿童中IDA的患病率及其相关因素。
对282名6至24个月看似健康的儿童进行血红蛋白浓度和平均红细胞体积(MCV)测定。还对贫血儿童(血红蛋白浓度<11.0 g/dl)测定血清铁(SI)、总铁结合力(TIBC)、血清铁蛋白(SF)和转铁蛋白饱和度(TS)。同时通过饮食记录获取当前饮食信息。
223名(79.1%)儿童患有贫血。所有年龄组的平均血红蛋白浓度均低于11.0 g/dl。40名(14.9%)儿童患有IDA(定义为贫血加以下两项或更多项——MCV<70fl、TS<10%或SF<10μg/dL)。IDA儿童的平均年龄(8.96±2.54个月)在统计学上低于无IDA儿童的平均年龄10.94±4.55个月(p = 0.016)。每周饮食中蔬菜和动物蛋白摄入少于三次均与IDA显著相关。
本研究中IDA的患病率较高,尤其是在12个月龄之前,每周平均摄入量少于三次或摄入动物蛋白和蔬菜等富含铁的食物与IDA显著相关。应强调在纯母乳喂养后饮食中添加富含铁的食物,以降低这些儿童中IDA的患病率。