[哈巴罗夫斯克2006年浆液性脑膜炎疫情病原体埃可6型病毒的分子流行病学]

[Molecular epidemiology of ECHO 6 virus, the causative agent of the 2006 outbreak of serous meningitis in Khabarovsk].

作者信息

Lukashev A N, Reznik V I, Ivanova O E, Eremeeva T P, Karavianskaia T N, Pereskokova M A, Lebedeva L A, Lashkevich V A, Mikhaĭlov M I

出版信息

Vopr Virusol. 2008 Jan-Feb;53(1):16-21.

PMID:18318129

Abstract

A total of 3194 cases of enterovirus meningitis were notified in the Russian Federation in 2005, of them there were 1434 cases in the Khabarovsk Territory. Enteroviruses were isolated from 1020 out of the virologically studied 1362 patients from the Khabarovsk Territory. Viruses E6 and E30 were isolated in 80 and 14.7% of cases, respectively. E1, E3, E7, E33, Coxsackie virus B1, B4, B5, and A10 were sporadically detected. The E6 strains isolated in Komsomolsk-on-Amur were identical while E6 strains isolated in Khabarovsk belonged to two different genotypes and greatly differed from those isolated in Konsomolsk-on-Amur. The virus E30 strains isolated in Khabarovsk and Komsomolsk-on-Amur had a 1% difference in VP1 genome nucleotide sequence and belonged to E30 subtype that circulated in Russia and Kazakhstan in 2004-2005.

摘要

2005年，俄罗斯联邦共报告了3194例肠道病毒脑膜炎病例，其中哈巴罗夫斯克边疆区有1434例。在哈巴罗夫斯克边疆区接受病毒学检查的1362名患者中，有1020例分离出了肠道病毒。病毒E6和E30分别在80%和14.7%的病例中被分离出来。E1、E3、E7、E33、柯萨奇病毒B1、B4、B5和A10被偶尔检测到。在阿穆尔河畔共青城分离出的E6毒株是相同的，而在哈巴罗夫斯克分离出的E6毒株属于两种不同的基因型，与在阿穆尔河畔共青城分离出的毒株有很大差异。在哈巴罗夫斯克和阿穆尔河畔共青城分离出的病毒E30毒株在VP1基因组核苷酸序列上有1%的差异，属于2004 - 2005年在俄罗斯和哈萨克斯坦流行的E30亚型。