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新西兰阿什伯顿无菌性脑膜炎爆发的临床、实验室和分子流行病学：由三重重组埃可病毒引起。

Clinical, Laboratory, and Molecular Epidemiology of an Outbreak of Aseptic Meningitis Due to a Triple-Recombinant Echovirus in Ashburton, New Zealand.

机构信息

Microbiology Department, Virology/Serology Section, Canterbury Health Laboratories, Christchurch 8011, New Zealand.

Department of Infectious Diseases, Christchurch Hospital, Christchurch 8011, New Zealand.

出版信息

Viruses. 2022 Mar 22;14(4):658. doi: 10.3390/v14040658.

DOI:10.3390/v14040658
PMID:35458388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9030895/
Abstract

Here, we describe a small enterovirus outbreak including nine cases of aseptic meningitis in a New Zealand hospital in 2017. Most patients had a lymphocytic predominance in the CSF, their length of stay was short, and there were no paediatric cases or ICU admissions. VP1 genotyping revealed that the outbreak was caused by an echovirus E30 strain closely related to strains reported from the US, UK, Brazil, and Denmark. They all form a separate cluster within lineage "h", which leads to the proposal of establishing a new lineage tentatively named "j" for this group of echovirus E30 strains. However, whole genome sequencing and reference mapping to echovirus E30 sequences showed very poor mapping of reads to the 3' half of the genome. Further bioinformatic analysis indicated that the causative agent of this outbreak might be a mosaic triple-recombinant enterovirus composed of echovirus E6, echovirus E11, and echovirus E30 genome segments.

摘要

在这里，我们描述了 2017 年新西兰一家医院发生的一起包括 9 例无菌性脑膜炎的小肠道病毒爆发。大多数患者的 CSF 以淋巴细胞为主，住院时间短，无儿科病例或 ICU 入院。VP1 基因分型显示，此次爆发是由与来自美国、英国、巴西和丹麦的报道菌株密切相关的 E 组 30 型肠道病毒引起的。它们都在“h”谱系内形成一个单独的聚类，这导致提议为这组 E 组 30 型肠道病毒建立一个新的谱系，暂命名为“j”。然而，全基因组测序和对肠道病毒 E30 序列的参考映射显示，读段与基因组 3' 端的映射非常差。进一步的生物信息学分析表明，此次爆发的病原体可能是一种由肠道病毒 E6、E11 和 E30 基因组片段组成的嵌合三重重组肠道病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/43710fffcdec/viruses-14-00658-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/aa071dd34b6e/viruses-14-00658-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/def2fd348382/viruses-14-00658-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/5ac7e59da9f9/viruses-14-00658-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/43710fffcdec/viruses-14-00658-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/aa071dd34b6e/viruses-14-00658-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/def2fd348382/viruses-14-00658-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/5ac7e59da9f9/viruses-14-00658-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c7/9030895/43710fffcdec/viruses-14-00658-g004.jpg

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