Tropinskaia O F, Serova N K, Aronov M S, Kobiakov G L
Vestn Oftalmol. 2008 Jan-Feb;124(1):14-9.
Intraocular lymphoma was encountered in 11.4% of the 79 examined patients with malignant lymphoma of the central nervous system. In most cases it had occurred long on an average of 26 months before the development of neurological manifestations and the diagnosis of cerebral lymphoma. Biomicroscopy showed intraocular lymphoma to manifest itself as corneal endothelial precipitation of translucent corpuscles, opacity of the vitreous body, and its posterior detachment. Isolated intraocular lymphoma has been misinterpreted as uveitis of unclear etiology. In this connection, resistance to steroidal and antibacterial therapy should be an indication for diagnostic vitrectomy, followed by an immunohistochemical study of a biopsy specimen. The intraarterial administration of methotrexate, by breaking the blood-brain barrier, caused regression of cerebral lymphoma, but did not result in that of intraocular lymphoma, on this basis the authors consider the intravitreal injection of the agent to be indicated.
在79例接受检查的中枢神经系统恶性淋巴瘤患者中，眼内淋巴瘤的发生率为11.4%。在大多数情况下，它平均在神经症状出现和脑淋巴瘤诊断前26个月就已发生。生物显微镜检查显示，眼内淋巴瘤表现为角膜内皮出现半透明小体沉淀、玻璃体混浊及其后脱离。孤立性眼内淋巴瘤曾被误诊为病因不明的葡萄膜炎。因此，对类固醇和抗菌治疗无反应应作为诊断性玻璃体切除术的指征，随后对活检标本进行免疫组织化学研究。动脉内注射甲氨蝶呤可突破血脑屏障，使脑淋巴瘤消退，但对眼内淋巴瘤无效，基于此，作者认为应行玻璃体内注射该药。
