Gordon I, Anderson P J, Orton M, Evans K
Department of Radiology, Hospital for Sick Children, London, England.
J Nucl Med. 1991 Sep;32(9):1704-8.
Dynamic renal scintigraphy using technetium-99m mercaptoacetylglycylglycylglycine (MAG3) has been described in adults, and clearance values have been established using multiple plasma samples. This study of renal clearance has compared two fundamentally different gamma camera techniques (both of which require a single blood sample) with the multiple blood sampling technique in children (n = 30). Results show that a 40-min dynamic 99mTc-MAG3 renal scintigram coupled with a single plasma sample will allow analysis of the data so that clearance values, which are similar to those from multiple plasma samples, may be calculated. The curve generated from the cardiac region of interest (ROI) provided clearances values that had a high correlation coefficient (0.939-0.951) compared to the multiple-plasma sample technique immaterial of the timing of the blood sample. The renal uptake method of clearance had a lower correlation coefficient (0.89-0.92), which varied with the timing of the blood sample compared to the multiple-plasma sampling technique. This study has demonstrated that an extended gamma camera acquisition coupled with a single-plasma sample may be used for quantitative renal function studies using 99mTc-MAG3.
使用锝-99m巯基乙酰甘氨酰甘氨酰甘氨酸（MAG3）进行的动态肾闪烁显像已在成人中有所描述，并且已通过采集多个血浆样本确定了清除率值。这项关于肾清除率的研究在儿童（n = 30）中比较了两种根本不同的γ相机技术（两者都只需采集一份血样）与多次采血技术。结果表明，结合一份血浆样本的40分钟动态99mTc-MAG3肾闪烁显像能够对数据进行分析，从而计算出与多次血浆样本所得结果相似的清除率值。由心脏感兴趣区（ROI）生成的曲线所提供的清除率值与多次血浆样本技术相比具有较高的相关系数（0.939 - 0.951），且与血样采集时间无关。与多次血浆采样技术相比，肾摄取清除率方法的相关系数较低（0.89 - 0.92），并且会随血样采集时间而变化。这项研究表明，结合一份血浆样本的延长γ相机采集可用于使用99mTc-MAG3进行的定量肾功能研究。
