Keske U, Cordes M, Hosten N, Roll D, Hunger J, Felix R
Strahlenklinik mit Poliklinik, Universitätsklinikum Rudolf Virchow, Berlin, BRD.
Nuklearmedizin. 1990 Jun;29(3):93-100.
Using labelled MAG3 (n = 172) or OIH (n = 102) the results of three different techniques of calculating renal clearance were compared. The following techniques were used: Tauxe (single plasma concentration determination), Oberhausen (modified, combined partial body and plasma disappearance clearance) and Winkler (partial body clearance). For OIH, linear regression analysis revealed a positive correlation of Tauxe and Oberhausen clearances with a correlation coefficient (r) of 0.90 and a mean ratio (mean) Oberhausen/Tauxe clearances of 1.03. For MAG3, the Oberhausen values were found to be significantly lower than the Tauxe values with an equally good correlation. For this radiopharmaceutical the Winkler values were significantly higher than the Tauxe and Oberhausen values. For OIH, no such difference was noted. However, the correlation coefficient was significantly lower. Whereas with the Tauxe method, a mean ratio MAG3-/OIH clearances of 0.62 was observed in an earlier investigation, from the present data a ratio of 0.53 is calculated for the Oberhausen clearance. The difference between the Tauxe and Oberhausen clearances with MAG3 is of importance when comparing clearance values obtained with clearance calculation techniques and for establishing normal values for the MAG3 clearance.
使用标记的巯基乙酰三甘氨酸（MAG3，n = 172）或碘奥酮（OIH，n = 102），比较了三种不同计算肾清除率技术的结果。采用了以下技术：陶克斯（单次血浆浓度测定）、奥伯豪森（改良的、结合部分身体和血浆消失清除率）和温克勒（部分身体清除率）。对于OIH，线性回归分析显示陶克斯清除率和奥伯豪森清除率呈正相关，相关系数（r）为0.90，奥伯豪森/陶克斯清除率的平均比值为1.03。对于MAG3，发现奥伯豪森值显著低于陶克斯值，相关性同样良好。对于这种放射性药物，温克勒值显著高于陶克斯值和奥伯豪森值。对于OIH，未观察到此类差异。然而，相关系数显著较低。在早期研究中，使用陶克斯方法观察到MAG3与OIH清除率的平均比值为0.62，根据目前的数据，奥伯豪森清除率的比值计算为0.53。在比较用清除率计算技术获得的清除率值以及确定MAG3清除率的正常值时，MAG3的陶克斯清除率和奥伯豪森清除率之间的差异很重要。
