Raucher Drazen, Massodi Iqbal, Bidwell Gene L
University of Mississippi Medical Center, Department of Biochemistry, 2500 North State Street, Jackson, MS 39216, USA.
Expert Opin Drug Deliv. 2008 Mar;5(3):353-69. doi: 10.1517/17425247.5.3.353.
Current chemotherapy treatment of solid tumors is limited due to a lack of specific delivery of the drugs to the tumor, leading to systemic toxicity. Therefore, it is necessary to develop targeted cancer therapies and tumor-targeted drug carriers. The authors review the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutics. The authors searched Medline for articles concerning the application of ELP as a drug delivery vector for small molecule drugs and therapeutic peptides. ELP has been demonstrated to be a promising thermally targeted carrier. Further examination of the in vivo biodistribution and efficacy will provide the necessary data to advance ELP technology toward the ultimate goal of human therapeutics.
由于缺乏将药物特异性递送至肿瘤的能力，目前实体瘤的化疗治疗受到限制，这会导致全身毒性。因此，有必要开发靶向癌症疗法和肿瘤靶向药物载体。作者综述了弹性蛋白样多肽（ELP）作为治疗药物热靶向递送潜在载体的发展情况。作者在医学文献数据库（Medline）中搜索了有关ELP作为小分子药物和治疗性肽的药物递送载体应用的文章。ELP已被证明是一种有前景的热靶向载体。对其体内生物分布和疗效的进一步研究将提供必要的数据，以推动ELP技术朝着人类治疗的最终目标发展。
