McGeachy Mandy J, Cua Daniel J
Schering-Plough Biopharma (Formerly DNAX Research), 901 California Avenue, Palo Alto, CA 94304, United States.
Semin Immunol. 2007 Dec;19(6):372-6. doi: 10.1016/j.smim.2007.10.012. Epub 2007 Dec 3.
IL-23--produced by dendritic cells--and Th17 cells have both been identified as major factors involved in autoimmune inflammation, yet their relationship with each other remains controversial. This review aims to describe the initial discovery of Th17 cells, their subsequent characterization as a unique T helper subset in mouse and man, as well as the mechanisms involved in regulating these cells. Finally, the roles of IL-23 in inflammatory diseases in relation to Th17 function will be discussed.
由树突状细胞产生的白细胞介素-23（IL-23）和辅助性T细胞17（Th17）细胞均已被确定为参与自身免疫性炎症的主要因素，然而它们彼此之间的关系仍存在争议。本综述旨在描述Th17细胞的最初发现、其随后作为小鼠和人类中独特的辅助性T细胞亚群的特征，以及调节这些细胞的相关机制。最后，将讨论IL-23在与Th17功能相关的炎症性疾病中的作用。
