Ghilardi Nico, Ouyang Wenjun
Department of Molecular Biology, Genentech Inc., 1-DNA Way, South San Francisco, CA 94080, USA.
Semin Immunol. 2007 Dec;19(6):383-93. doi: 10.1016/j.smim.2007.10.016. Epub 2008 Jan 14.
T helper (TH) cells can assume different phenotypes characterized by the secretion of distinct effector molecules. Interferon-gamma producing TH1 and IL-4 producing TH2 cells have long been recognized as important mediators of host defense, whereas regulatory T cells are known to suppress T cell responses. Recently, TH17 cells were characterized as a novel CD4(+) subset that preferentially produces IL-17, IL-17F, and IL-22 as the signature cytokines. TH17 cells appear to play a critical role in sustaining the inflammatory response and their presence is closely associated with autoimmune disease, which makes them an attractive therapeutic target. In this review, we focus on the mechanisms that regulate the differentiation of naive T cells into TH17 cells and on TH17 effector cytokines, as they represent opportunities for therapeutic intervention.
辅助性T（TH）细胞可呈现不同的表型，其特征在于分泌不同的效应分子。长期以来，产生干扰素-γ的TH1细胞和产生白细胞介素-4的TH2细胞一直被认为是宿主防御的重要介质，而调节性T细胞则已知可抑制T细胞反应。最近，TH17细胞被鉴定为一种新型的CD4(+)亚群，该亚群优先产生白细胞介素-17、白细胞介素-17F和白细胞介素-22作为标志性细胞因子。TH17细胞似乎在维持炎症反应中起关键作用，并且它们的存在与自身免疫性疾病密切相关，这使得它们成为一个有吸引力的治疗靶点。在本综述中，我们重点关注调节初始T细胞分化为TH17细胞的机制以及TH17效应细胞因子，因为它们代表了治疗干预的机会。
