Sillero-Arenas M, Rodriguez-Contreras R, Delgado-Rodriguez M, Bueno-Cavanillas A, Galvez-Vargas R
Unit of Health Programs, Provincial Office for Health, Jaen, Spain.
Acta Obstet Gynecol Scand. 1991;70(2):143-8. doi: 10.3109/00016349109006197.
Original papers on the oral contraceptive use-cervical cancer relationship are analysed. The purpose of this study was to ascertain the biases of the original articles collected in relation to various characteristics of any investigation. Papers were located by using MEDLINE, reviewing the references of each article identified by MEDLINE, and then reviewing the contents of those journals in which an original could be published. Fifty-five publications (from 49 original studies) were graded as to quality and classified as biased or unbiased. Nineteen studies were considered unbiased. The most common biases identified were confounding, detection bias, and misclassification bias. The pattern of research/publication has changed since the association began to be analysed: articles shift from gynecological to cancer and epidemiological journals; the number of studies performed by gynecologists alone and pathologists alone decreases, while studies performed by epidemiologists alone or in collaboration with gynecologists increase. This collaboration produced studies with fewer biases. It is suggested that the above mentioned collaboration should be increased to improve access to, and then the application of the results obtained in the original studies on oral contraceptives and cervical cancer.
对关于口服避孕药使用与宫颈癌关系的原始论文进行了分析。本研究的目的是确定所收集的原始文章在与任何调查的各种特征相关方面的偏差。通过使用医学文献数据库（MEDLINE）查找论文，查阅MEDLINE识别出的每篇文章的参考文献，然后查阅那些可能发表原始论文的期刊内容。对55篇出版物（来自49项原始研究）进行了质量分级，并分类为有偏差或无偏差。19项研究被认为无偏差。所识别出的最常见偏差是混杂、检测偏差和错误分类偏差。自从开始分析这种关联以来，研究/发表模式发生了变化：文章从妇科期刊转向癌症和流行病学期刊；仅由妇科医生和仅由病理学家进行的研究数量减少，而仅由流行病学家或与妇科医生合作进行的研究数量增加。这种合作产生的研究偏差较少。建议应增加上述合作，以改善获取口服避孕药与宫颈癌原始研究结果的途径，并进而促进这些结果的应用。
