Delgado Rodríguez M, Sillero Arenas M, Rodríguez-Contreras R, Bueno Cavanillas A, Martín Moreno J M, Gálvez Vargas R
Departamento de Medicina Preventiva, Facultad de Medicina, Granada.
Gac Sanit. 1991 Mar-Apr;5(23):59-67. doi: 10.1016/s0213-9111(91)71048-0.
The power of the association between oral contraceptives and breast cancer was analysed in all the papers published up to date. Seventy-seven publications (from 44 studies) were collected and graded as to quality using meta-analytical methods. Power achieved a figure of greater than or equal to 0.8 in a 10.8% of the associations studied. It showed a significant relationship with the existence of a significant relative risk of the oral contraceptives for breast cancer. The relationship with the sample size of a study was not linear. Power did not show any significant relationship to other variables related to the design of a study (apart from matching, being the power higher in unmatched studies), or to the biases detected, although studies considered as unbiased yielded a higher power. Logistic regression analysis included as predictors of a power greater than or equal to 0.80 the existence of a significant relative risk and the lack of biases in a research.
对截至目前发表的所有论文中口服避孕药与乳腺癌之间关联的效力进行了分析。收集了77篇出版物（来自44项研究），并使用荟萃分析方法对质量进行分级。在所研究的关联中，10.8%的关联效力达到了大于或等于0.8的数值。它显示出与口服避孕药对乳腺癌存在显著相对风险之间存在显著关系。与研究样本量的关系并非线性。效力与研究设计的其他变量（除匹配外，未匹配研究中的效力更高）或检测到的偏倚均未显示出任何显著关系，尽管被认为无偏倚的研究产生的效力更高。逻辑回归分析将存在显著相对风险和研究中无偏倚作为效力大于或等于0.80的预测因素。
