Panza Francesco, D'Introno Alessia, Colacicco Anna M, Capurso Cristiano, Del Parigi Angelo, Caselli Richard J, Todarello Orlando, Pellicani Vincenza, Santamato Andrea, Scapicchio Pierluigi, Maggi Stefania, Scafato Emanuele, Gandin Claudia, Capurso Antonio, Solfrizzi Vincenzo
Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy.
Dement Geriatr Cogn Disord. 2008;25(4):336-46. doi: 10.1159/000119522. Epub 2008 Mar 5.
We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI.
A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale.
Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85-1.84, chi(2) = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI.
In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI.
我们评估了抑郁症状对3.5年随访后轻度认知障碍（MCI）发病率的影响，并评估了抑郁症状与MCI发病的血管危险因素之间的相互作用。
在意大利老龄化纵向研究的第一次和第二次调查中，对来自5632名65至84岁受试者样本中的2963人进行了认知和功能评估，这是一项为期3.5年随访的前瞻性队列研究。MCI和痴呆症根据当前临床标准进行分类。使用老年抑郁量表测量抑郁症状。
在2963名参与者中，第一次调查诊断出139例MCI现患病例。在3.5年的随访期间，诊断出105例新的MCI事件。我们未观察到抑郁症状与MCI发病之间存在任何显著关联（风险比=1.25，95%置信区间=0.85 - 1.84，卡方=1.30，p<0.25）。没有社会人口统计学变量或血管危险因素改变抑郁症状与MCI发病之间的关系。
在我们的人群中，抑郁症状与MCI发病率无关。我们的研究结果不支持社会人口统计学变量或血管危险因素在抑郁症状与MCI发病之间的联系中起作用。
