Hakim Antoine M
Neuroscience Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada K1Y 4E9.
Cardiovasc Psychiatry Neurol. 2011;2011:649629. doi: 10.1155/2011/649629. Epub 2011 Dec 15.
The literature emphasizes the risk of depression after a stroke. Less well known is the fact that depression may be as big a risk factor for strokes as hypertension, particularly in the older age group. This article reviews the risk for stroke and cognitive impairment consequent to depression, and describes the cardiovascular and immunological mechanisms that would appear to link depression to its cerebrovascular consequences. As well, the article refers to the brain imaging signatures that may allow prediction of impending brain injury. Finally, some questions that might be explored by future research are suggested, and some practical means to identify and help those at risk for the development of depression-associated vascular disease of the brain are suggested.
文献强调了中风后患抑郁症的风险。鲜为人知的是，抑郁症可能与高血压一样，是中风的重大风险因素，尤其是在老年人群体中。本文回顾了抑郁症导致中风和认知障碍的风险，并描述了似乎将抑郁症与其脑血管后果联系起来的心血管和免疫机制。此外，本文还提到了可能有助于预测即将发生的脑损伤的脑成像特征。最后，提出了一些未来研究可能探讨的问题，并提出了一些识别和帮助有患抑郁症相关脑血管疾病风险人群的实际方法。
