肝硬化患者中替扎尼定诱发的低血压 - Suppr

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Tizanidine-induced hypotension in patients with liver cirrhosis.

作者信息

Momo Kenji, Homma Masato, Abei Makoto, Hyodo Ichinosuke, Kohda Yukinao

出版信息

Eur J Clin Pharmacol. 2008 Jun;64(6):647-8. doi: 10.1007/s00228-008-0469-7.

DOI:10.1007/s00228-008-0469-7

PMID:18320182

Abstract

摘要

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Tizanidine-induced hypotension in patients with liver cirrhosis.肝硬化患者中替扎尼定诱发的低血压

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Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.CYP1A2 强抑制剂与替扎尼定相关低血压风险的联合处方：一项回顾性队列研究。

Clin Pharmacol Ther. 2019 Mar;105(3):703-709. doi: 10.1002/cpt.1233. Epub 2018 Oct 18.

Hypotension due to interaction between lisinopril and tizanidine.赖诺普利与替扎尼定相互作用所致低血压。

Ann Pharmacother. 2004 Nov;38(11):1840-3. doi: 10.1345/aph.1E161. Epub 2004 Sep 21.

Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.一名接受血管紧张素转换酶抑制剂治疗慢性高血压的患者，在开始使用替扎尼定后出现低血压。

J Child Neurol. 2000 Dec;15(12):818-9. doi: 10.1177/088307380001501211.

Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S.齐拉西酮与环丙沙星同时使用后不良事件风险：美国队列研究

Am J Emerg Med. 2022 May;55:147-151. doi: 10.1016/j.ajem.2022.03.008. Epub 2022 Mar 10.

Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.伴有替扎尼定和赖诺普利治疗的低血压和心动过缓。

Am J Health Syst Pharm. 2010 Oct 1;67(19):1606-10. doi: 10.2146/ajhp090657.

Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.鞘内注射可乐定和替扎尼定在神经性疼痛大鼠模型中的抗痛觉过敏作用及副作用

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Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders.替扎尼定。关于其在治疗与脑和脊髓疾病相关的痉挛方面的药理学、临床疗效及耐受性的综述。

Drugs. 1997 Mar;53(3):435-52. doi: 10.2165/00003495-199753030-00007.

Neurogenic orthostatic hypotension induced by tizanidine.替扎尼定诱发的神经源性直立性低血压。

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A case of tizanidine-induced hepatic injury.

J Hepatol. 1996 Nov;25(5):772-3. doi: 10.1016/s0168-8278(96)80252-2.

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Drugs or dissection? Unraveling a diagnostic puzzle in the ED: A case report on Tizanidine-Nifedipine interaction.药物还是解剖？解开急诊室的诊断谜题：一例关于替扎尼定-硝苯地平相互作用的病例报告

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A severe tremor caused by a beta2 agonist in a patient with asthma-chronic obstructive pulmonary disease overlap.一名患有哮喘-慢性阻塞性肺疾病重叠综合征的患者因β2激动剂引发严重震颤。

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本文引用的文献

Drug interaction of tizanidine and ciprofloxacin: case report.替扎尼定与环丙沙星的药物相互作用：病例报告

Clin Pharmacol Ther. 2006 Dec;80(6):717-9. doi: 10.1016/j.clpt.2006.08.017.

Liver disease selectively modulates cytochrome P450--mediated metabolism.肝脏疾病选择性地调节细胞色素P450介导的代谢。

Clin Pharmacol Ther. 2006 Sep;80(3):235-45. doi: 10.1016/j.clpt.2006.05.006.

Quantification of tizanidine in human plasma by liquid chromatography coupled to tandem mass spectrometry.采用液相色谱-串联质谱法对人血浆中的替扎尼定进行定量分析。

Rapid Commun Mass Spectrom. 2006;20(15):2286-92. doi: 10.1002/rcm.2592.

The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population.细胞色素P450 1A2（CYP1A2）基因的G-113A多态性影响中国人群的咖啡因代谢率。

Clin Pharmacol Ther. 2005 Sep;78(3):249-59. doi: 10.1016/j.clpt.2005.05.012.

Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.环丙沙星通过抑制替扎尼定的细胞色素P450 1A2介导的首过代谢，大大提高了替扎尼定的血药浓度和降压效果。

Clin Pharmacol Ther. 2004 Dec;76(6):598-606. doi: 10.1016/j.clpt.2004.08.018.

Drug interaction of tizanidine and fluvoxamine.替扎尼定与氟伏沙明的药物相互作用。

Clin Pharmacol Ther. 2004 Nov;76(5):509-10. doi: 10.1016/j.clpt.2004.08.003.

Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction.氟伏沙明会大幅提高替扎尼定的浓度及药效：这是一种具有潜在危险性的相互作用。

Clin Pharmacol Ther. 2004 Apr;75(4):331-41. doi: 10.1016/j.clpt.2003.12.005.

Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.替扎尼定在体外主要由细胞色素P450 1A2代谢。

Br J Clin Pharmacol. 2004 Mar;57(3):349-53. doi: 10.1046/j.1365-2125.2003.02028.x.

Mechanisms of tizanidine action on spasticity.

Acta Neurol Scand. 1994 Apr;89(4):274-9. doi: 10.1111/j.1600-0404.1994.tb01680.x.

A peek at the Child-Turcotte classification.一瞥儿童-图尔科特分类法。

Hepatology. 1981 Nov-Dec;1(6):673-6. doi: 10.1002/hep.1840010617.

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