血栓素受体拮抗剂对自发性高血压大鼠雌激素诱导的子宫营养反应的影响。
The effects of thromboxane receptor antagonists on oestrogen-induced uterotrophic responses in the spontaneously hypertensive rat.
作者信息
Kerr M B, Marshall K, Senior J
机构信息
School of Pharmacy, University of Bradford.
出版信息
Br J Pharmacol. 1991 Jun;103(2):1363-6. doi: 10.1111/j.1476-5381.1991.tb09794.x.
Abstract
- The possible role of thromboxane in the uterotrophic response to oestrogen, in the spontaneously hypertensive rat was investigated by use of the thromboxane receptor antagonists EP092, AH23848 and BM 13.505. 2. The parameters studied were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights and the concentrations of cytosolic and nuclear oestrogen receptors. 3. The antagonists attenuated oestradiol-induced uterine blood flow and significantly reduced both wet and dry uterine weight. These changes were accompanied by decreases in nuclear oestrogen receptor levels. 4. The results suggest a supportive role for thromboxane in oestradiol-induced uterine growth.
摘要
- 通过使用血栓素受体拮抗剂EP092、AH23848和BM 13.505，研究了血栓素在自发性高血压大鼠子宫对雌激素营养反应中的可能作用。2. 所研究的参数包括子宫血流量（通过微球技术测量）、子宫湿重和干重以及胞质和核雌激素受体的浓度。3. 拮抗剂减弱了雌二醇诱导的子宫血流量，并显著降低了子宫湿重和干重。这些变化伴随着核雌激素受体水平的降低。4. 结果表明血栓素在雌二醇诱导的子宫生长中起支持作用。
相似文献
1
The effects of thromboxane receptor antagonists on oestrogen-induced uterotrophic responses in the spontaneously hypertensive rat.血栓素受体拮抗剂对自发性高血压大鼠雌激素诱导的子宫营养反应的影响。
Br J Pharmacol. 1991 Jun;103(2):1363-6. doi: 10.1111/j.1476-5381.1991.tb09794.x.
2
Modification of the rat uterine response to oestrogen and tamoxifen by thromboxane antagonists.血栓素拮抗剂对大鼠子宫雌激素和他莫昔芬反应的影响
Br J Pharmacol. 1991 Mar;102(3):742-6. doi: 10.1111/j.1476-5381.1991.tb12243.x.
3
The role of thromboxane in the uterotrophic response in the gravid normotensive and spontaneously hypertensive rat.血栓素在妊娠正常血压大鼠和自发性高血压大鼠子宫营养反应中的作用。
J Endocrinol. 1992 Nov;135(2):257-61. doi: 10.1677/joe.0.1350257.
4
Characterization of contraction-mediating prostanoid receptors in human hand veins: effects of the thromboxane receptor antagonists BM13,505 and AH23848.人手部静脉中介导收缩的前列腺素受体的特性：血栓素受体拮抗剂BM13,505和AH23848的作用
Acta Physiol Scand. 1991 Jan;141(1):79-86. doi: 10.1111/j.1748-1716.1991.tb09047.x.
5
The effect of mepyramine and ranitidine on the oestrogen and anti-oestrogen stimulated rat uterus.美吡拉敏和雷尼替丁对雌激素和抗雌激素刺激的大鼠子宫的作用。
Br J Pharmacol. 1986 Sep;89(1):251-6. doi: 10.1111/j.1476-5381.1986.tb11142.x.
6
A study on the effect of a single dose of tamoxifen on uterine hyperaemia and growth in the rat.单剂量他莫昔芬对大鼠子宫充血和生长影响的研究。
Br J Pharmacol. 1987 Oct;92(2):429-35. doi: 10.1111/j.1476-5381.1987.tb11339.x.
7
The effect of a single dose of oestradiol on tamoxifen-induced uterine hyperaemia and growth in the rat.单次剂量雌二醇对他莫昔芬诱导的大鼠子宫充血及生长的影响。
Br J Pharmacol. 1989 Oct;98(2):383-8. doi: 10.1111/j.1476-5381.1989.tb12608.x.
8
GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro.GR32191，一种在体外对血小板、血管及气道平滑肌具有高效且特异性的血栓素A2受体阻断药物。
Br J Pharmacol. 1989 Jul;97(3):783-94. doi: 10.1111/j.1476-5381.1989.tb12017.x.
9
The role of endogenous thromboxane in contractions to U46619, oxygen, 5-HT and 5-CT in the human isolated umbilical artery.内源性血栓素在人离体脐动脉对U46619、氧、5-羟色胺和5-羧色胺收缩反应中的作用
Br J Pharmacol. 1991 May;103(1):1079-84. doi: 10.1111/j.1476-5381.1991.tb12303.x.
10
Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles.
J Pharmacol Exp Ther. 1992 Feb;260(2):789-94.
引用本文的文献
1
Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine.雌二醇诱导鹌鹑输卵管磷脂类组成的变化：在烯基酰基甘油磷酸乙醇胺中二十二碳六烯酸对花生四烯酸的特异性取代。
Biochem J. 1994 Jul 15;301 ( Pt 2)(Pt 2):361-6. doi: 10.1042/bj3010361.
本文引用的文献
1
Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells.单克隆抗体将雌激素受体定位在靶细胞核中。
Nature. 1984;307(5953):745-7. doi: 10.1038/307745a0.
2
Spontaneous hypertension in rats.
Int Rev Exp Pathol. 1969;7:227-70.
3
Neurogenic and humoral factors controlling vascular resistance in the spontaneously hypertensive rat.控制自发性高血压大鼠血管阻力的神经源性和体液性因素。
Circ Res. 1974 Nov;35(5):764-74. doi: 10.1161/01.res.35.5.764.
4
Prostaglandin synthesis from endogenous and exogenous arachidonic acid in the rat uterus. Effect of estradiol and progesterone.大鼠子宫中内源性和外源性花生四烯酸的前列腺素合成。雌二醇和孕酮的作用。
Prostaglandins Leukot Med. 1985 Jun;18(3):321-36. doi: 10.1016/0262-1746(85)90065-4.
5
Further studies on prostaglandin and thromboxane production by the rat uterus during the oestrous cycle.大鼠发情周期中子宫前列腺素和血栓素生成的进一步研究。
J Reprod Fertil. 1985 Mar;73(2):391-9. doi: 10.1530/jrf.0.0730391.
6
A study on the effect of a single dose of tamoxifen on uterine hyperaemia and growth in the rat.单剂量他莫昔芬对大鼠子宫充血和生长影响的研究。
Br J Pharmacol. 1987 Oct;92(2):429-35. doi: 10.1111/j.1476-5381.1987.tb11339.x.
7
Effect of actinomycin D on prostaglandin synthesis by and output from the guinea-pig uterus.放线菌素D对豚鼠子宫前列腺素合成及释放的影响。
Prostaglandins Leukot Med. 1987 Jul;28(2):153-68. doi: 10.1016/0262-1746(87)90160-0.
8
AH23848: a thromboxane receptor-blocking drug that can clarify the pathophysiologic role of thromboxane A2.AH23848：一种能阐明血栓素A2病理生理作用的血栓素受体阻断药物。
Circulation. 1985 Dec;72(6):1208-18. doi: 10.1161/01.cir.72.6.1208.
9
Thromboxane synthetase inhibitors, thromboxane receptor antagonists, and aspirin in cardiovascular disease.血栓素合成酶抑制剂、血栓素受体拮抗剂及阿司匹林在心血管疾病中的应用
Ration Drug Ther. 1985 Jul;19(7):1-7.
10
Modification of the rat uterine response to oestrogen and tamoxifen by thromboxane antagonists.血栓素拮抗剂对大鼠子宫雌激素和他莫昔芬反应的影响
Br J Pharmacol. 1991 Mar;102(3):742-6. doi: 10.1111/j.1476-5381.1991.tb12243.x.
Zotero 插件