血栓素拮抗剂对大鼠子宫雌激素和他莫昔芬反应的影响
Modification of the rat uterine response to oestrogen and tamoxifen by thromboxane antagonists.
作者信息
Kerr M B, Marshall K, Senior J
机构信息
Postgraduate School of Studies in Pharmacology, University of Bradford, West Yorkshire.
出版信息
Br J Pharmacol. 1991 Mar;102(3):742-6. doi: 10.1111/j.1476-5381.1991.tb12243.x.
Abstract
- The thromboxane receptor antagonists EP092, AH23848 and BM 13.505 were used to investigate the role of thromboxane in the uterotrophic response to oestradiol and tamoxifen. 2. The parameters examined were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights and the concentrations of cytosolic and nuclear oestrogen receptors. 3. Only EP092 potentiated the hyperaemic response to oestrogen but all three thromboxane antagonists inhibited oestradiol-stimulated uterine growth. This inhibition was accompanied by a decrease in nuclear oestrogen receptor concentration. 4. The uterotrophic response to tamoxifen was unaffected by the thromboxane antagonists. 5. The mechanism by which the thromboxane antagonists may be exerting their growth inhibitory effect is discussed, although, whether this effect can be attributed to blockade of thromboxane receptors or to some other mechanism is not clear from this study.
摘要
- 血栓素受体拮抗剂EP092、AH23848和BM 13.505被用于研究血栓素在子宫对雌二醇和他莫昔芬营养反应中的作用。2. 所检测的参数包括子宫血流量（通过微球技术测量）、子宫湿重和干重以及胞质和核雌激素受体的浓度。3. 只有EP092增强了对雌激素的充血反应，但所有三种血栓素拮抗剂均抑制雌二醇刺激的子宫生长。这种抑制伴随着核雌激素受体浓度的降低。4. 血栓素拮抗剂对他莫昔芬引起的子宫营养反应没有影响。5. 讨论了血栓素拮抗剂可能发挥其生长抑制作用的机制，不过，从本研究尚不清楚这种作用是否可归因于血栓素受体的阻断或其他某种机制。
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引用本文的文献
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The effects of thromboxane receptor antagonists on oestrogen-induced uterotrophic responses in the spontaneously hypertensive rat.血栓素受体拮抗剂对自发性高血压大鼠雌激素诱导的子宫营养反应的影响。
Br J Pharmacol. 1991 Jun;103(2):1363-6. doi: 10.1111/j.1476-5381.1991.tb09794.x.
本文引用的文献
1
Anti-oestrogen modification of uterine responses to oestrogen in the rat.
J Reprod Fertil. 1982 Sep;66(1):79-85. doi: 10.1530/jrf.0.0660079.
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Hypothalamic, pituitary and uterine cytoplasmic and nuclear oestrogen receptors and their relationship to the serum concentration of tamoxifen and its metabolite, 4-hydroxytamoxifen, in the ovariectomized rat.去卵巢大鼠下丘脑、垂体及子宫的细胞质和细胞核雌激素受体及其与他莫昔芬及其代谢产物4-羟基他莫昔芬血清浓度的关系。
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