Marinova-Mutafchieva L P, Chakalova G B, Goranov I T
Vopr Onkol. 1991;37(4):454-7.
Monoclonal antibodies (Ortho type) were used for immunocytochemical evaluation of cell-mediated immunity in peripheral blood from 29 patients with in situ (TisNoMo) and microinvasive (T1aNoMo) cervical carcinoma. The total number of T cells (OKT3+) was decreased in both patient groups compared to healthy volunteers. Marked difference between OKT4+ (helper/inducer) and OKT8+ (suppressor/cytotoxic) cells was observed OKT8+ level rose with advancement of disease, resulting in inverted OKT4+/OKT8+ ratio in T1aNoMo cancer patients. Antitumor immune resistance proved inhibited in both study groups manifesting itself in suppression of cell-mediated immunity.
采用单克隆抗体（Ortho型）对29例原位（TisNoMo）和微浸润（T1aNoMo）宫颈癌患者外周血中的细胞介导免疫进行免疫细胞化学评估。与健康志愿者相比，两组患者的T细胞总数（OKT3+）均减少。观察到OKT4+（辅助/诱导）细胞和OKT8+（抑制/细胞毒性）细胞之间存在显著差异，OKT8+水平随疾病进展而升高，导致T1aNoMo期癌症患者的OKT4+/OKT8+比值倒置。在两个研究组中均证实抗肿瘤免疫抵抗受到抑制，表现为细胞介导免疫受到抑制。
