Yaylali Olga Taskaya, Yilmaz Mustafa, Kiraç Fatma Suna, Değirmencioğlu Serkan, Akbulut Metin
Department of Nuclear Medicine, Pamukkale University, School of Medicine, Doktorlar Caddesi No. 42, Denizli 20100, Turkey.
World J Gastroenterol. 2008 Mar 7;14(9):1406-10. doi: 10.3748/wjg.14.1406.
To evaluate the relationship between gallbladder (GB) motor function and H pylori infection in the stomach.
All cases (86) underwent the 14C urea breath test (UBT). 14C-UBT was found as positive in 58 and negative in 28 dyspeptic patients. 14C-UBT was accepted as a gold standard test. Clo test and histopathologic examination were compared with the results of 14C-UBT in cases who tolerated upper gastrointestinal endoscopy procedure. Cholescintigraphy with 99mTc-mebrofenin was used to determine the parameters of GB motor function (GB filling and emptying time, half of the emptying time, ejection fraction at 30th and 60th min) in all patients.
We found the sensitivity and specificity as 88% and 86% for Clo test and as 89% and 80% for histologic evaluation, respectively. The parameters of GB function were not significantly different in H pylori positive and negative patients. The GB emptying was normal in both groups. Minimum GB filling time was 30 min in 34 of 86 cases (39.5%), filling was not observed in 2 cases. The GB ultrasonography (USG) results were normal for all cases and bile composition abnormality was not determined.
Our study showed that 14C-UBT is highly reliable method to detect the presence of H pylori. The presence of H pylori infection does ot directly affect the GB function.
评估胆囊（GB）运动功能与胃幽门螺杆菌（H pylori）感染之间的关系。
所有86例患者均接受了14C尿素呼气试验（UBT）。在58例消化不良患者中14C-UBT结果为阳性，28例为阴性。14C-UBT被视为金标准检测。对于能够耐受上消化道内镜检查的患者，将Clo试验和组织病理学检查结果与14C-UBT结果进行比较。所有患者均采用99mTc-美罗昔芬进行胆囊闪烁显像，以确定GB运动功能参数（GB充盈和排空时间、排空时间的一半、第30分钟和第60分钟时的射血分数）。
我们发现Clo试验的敏感性和特异性分别为88%和86%，组织学评估的敏感性和特异性分别为89%和80%。H pylori阳性和阴性患者的GB功能参数无显著差异。两组的GB排空均正常。86例中有34例（39.5%）的GB最短充盈时间为30分钟，2例未观察到充盈。所有病例的GB超声检查（USG）结果均正常，未发现胆汁成分异常。
我们的研究表明，14C-UBT是检测H pylori存在的高度可靠方法。H pylori感染的存在并不直接影响GB功能。
