心血管分子靶点的磁共振光学成像
MR-optical imaging of cardiovascular molecular targets.
作者信息
Nahrendorf Matthias, Sosnovik David E, Weissleder Ralph
机构信息
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Basic Res Cardiol. 2008 Mar;103(2):87-94. doi: 10.1007/s00395-008-0707-2.
Abstract
Our understanding of the intricate inflammation biology underlying atherosclerosis is rapidly progressing. Molecular imaging strategies, harnessing this body of knowledge, have been developed to visualize some key cellular and molecular events in plaque evolution and vulnerability. Here, we discuss recent advances in magnetic resonance and fluorescence imaging of key biomarkers including adhesion molecules, inflammatory cells, and enzyme activity. We discuss strengths and limitations of respective imaging technologies, and comment on the potential of multi-modality imaging approaches.
摘要
我们对动脉粥样硬化复杂炎症生物学的理解正在迅速发展。利用这一知识体系的分子成像策略已被开发出来，以可视化斑块演变和易损性中的一些关键细胞和分子事件。在这里，我们讨论了包括粘附分子、炎症细胞和酶活性在内的关键生物标志物的磁共振成像和荧光成像的最新进展。我们讨论了各自成像技术的优缺点，并对多模态成像方法的潜力进行了评论。
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