Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.
Vascul Pharmacol. 2013 Jan;58(1-2):31-8. doi: 10.1016/j.vph.2012.10.005. Epub 2012 Oct 26.
Molecular imaging is emerging as a key experimental tool for the identification of inflammatory cellular and molecular processes involved in the development of cardiovascular disease. This review summarises current molecular imaging approaches for the detection of vascular inflammation using a range of nano- and micro-sized contrast agents. We highlight strategies for detection of cell adhesion molecules, which are key regulators of endothelial activation and leukocyte recruitment in atherogenesis and ischaemia-reperfusion in jury. In particular, we address the properties of targeted microparticles of iron oxide (MPIO) for MRI detection of endothelial cell-specific activation of adhesion molecules in experimental models of atherosclerosis, acute vascular inflammation and ischaemia-reperfusion injury, which are otherwise undetectable by conventional imaging modalities. The ability of targeted MPIO to detect endothelial activation could enable early subclinical disease detection and development of novel therapeutic strategies. We discuss opportunities for further development and potential translation of targeted MPIO for clinical imaging of cardiovascular disease.
分子影像学正在成为识别心血管疾病发展过程中涉及的炎症细胞和分子过程的关键实验工具。本综述总结了目前使用一系列纳米级和微米级对比剂检测血管炎症的分子成像方法。我们强调了检测细胞黏附分子的策略，这些分子是动脉粥样硬化和缺血再灌注损伤中内皮细胞激活和白细胞募集的关键调节剂。特别是，我们讨论了靶向氧化铁微粒子（MPIO）的特性，用于 MRI 检测实验性动脉粥样硬化、急性血管炎症和缺血再灌注损伤中黏附分子的内皮细胞特异性激活，这些在常规成像方式下是无法检测到的。靶向 MPIO 检测内皮细胞激活的能力可以实现早期亚临床疾病的检测和新型治疗策略的发展。我们讨论了进一步开发和潜在转化靶向 MPIO 用于心血管疾病临床成像的机会。
