Autiero Maddalena, Cozzolino Rosanna, Laccetti Paolo, Marotta Marcello, Quarto Maria, Riccio Patrizia, Roberti Giuseppe
Dipartimento di Scienze Fisiche, Università di Napoli Federico II, Via Cinthia, 80126, Naples, Italy.
Lasers Med Sci. 2009 Mar;24(2):284-9. doi: 10.1007/s10103-007-0523-1. Epub 2008 Mar 7.
The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).
采用激光诱导荧光反射成像（FRI）技术，以血卟啉（HP）化合物作为外源性光学造影剂，对植入小动物体内的皮下人类肿瘤进行了体内早期检测研究。结果表明，在接种肿瘤细胞仅3天后，当肿瘤既不可见也不可触及时，仍有可能检测到肿瘤。然而，这种检测能力仅限于从给予HP后约100小时的时间窗口，并且肿瘤的光学对比度较低（<2）。
