Nogués X, Sentí M, Pedro-Botet J, Rubiés-Prat J, Vidal-Barraquer F
Department of Medicine, Hospital de la Esperanza, Barcelona, Spain.
Angiology. 1991 Aug;42(8):659-64. doi: 10.1177/000331979104200809.
The authors quantified serum lipoprotein (a) (Lp) (a) by enzymo-immuno-analysis in 86 outpatient men suffering peripheral vascular disease (PVD) and in 53 age-matched healthy men. They further measured serum cholesterol, serum triglycerides, low density lipoproteins-cholesterol, high density lipoproteins (HDL)-cholesterol and serum apolipoprotein B. Serum triglycerides were significantly increased in patients with PVD versus controls (148 +/- 8 and 114 +/- 7 mg/dL, mean +/- SEM). HDL-cholesterol levels were significantly lower in patients versus controls (36 +/- 1 and 43 +/- 2 mg/dL, respectively). Serum Lp(a) levels in patients with PVD were 20 +/- 2 mg/dL, whereas in controls they were 16 +/- 3 (p: NS). Serum Lp(a) concentrations were identical in smoker and nonsmoker patients. There was no correlation between Lp(a) concentration and the other lipid parameters. Conversely, as occurs in coronary heart disease and in cerebrovascular disease, Lp(a) does not seem to be a marker for PVD, although a trend toward a higher mean levels was found.
作者采用酶免疫分析法对86例患有外周血管疾病（PVD）的门诊男性患者和53例年龄匹配的健康男性的血清脂蛋白（a）[Lp（a）]进行了定量分析。他们还测定了血清胆固醇、血清甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白（HDL）胆固醇和血清载脂蛋白B。与对照组相比，PVD患者的血清甘油三酯显著升高（分别为148±8和114±7mg/dL，均值±标准误）。患者的HDL胆固醇水平显著低于对照组（分别为36±1和43±2mg/dL）。PVD患者的血清Lp（a）水平为20±2mg/dL，而对照组为16±3（p：无显著性差异）。吸烟和不吸烟患者的血清Lp（a）浓度相同。Lp（a）浓度与其他脂质参数之间无相关性。相反，尽管发现有平均水平升高的趋势，但与冠心病和脑血管疾病一样，Lp（a）似乎不是PVD的标志物。
