双薯蓣皂苷元吡嗪二聚体的合成：新型头霉素类似物
Synthesis of bis-diosgenin pyrazine dimers: new cephalostatin analogs.
作者信息
Shawakfeh Khaled Q, Al-Said Naim H, Al-Zoubi Raed M
机构信息
Department of Applied Chemical Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
出版信息
Steroids. 2008 Jul;73(6):579-84. doi: 10.1016/j.steroids.2008.01.012. Epub 2008 Jan 19.
Abstract
A convenient synthesis for bis-diosgenin pyrazine dimers, cephalostatin analogues is reported. These symmetrical dimeric steroid-pyrazines were obtained by the classical condensation of alpha-amino ketones, the most efficient method for pyrazine ring construction.
摘要
报道了一种用于双薯蓣皂苷元吡嗪二聚体（头霉素类似物）的简便合成方法。这些对称的二聚甾体 - 吡嗪是通过α - 氨基酮的经典缩合反应得到的，这是构建吡嗪环最有效的方法。
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