双-18,18'-去甲基利特嗪N的合成
Synthesis of Bis-18,18'-desmethyl Ritterazine N.
作者信息
Taber Douglass F, Joerger Jean-Michel
机构信息
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
出版信息
J Org Chem. 2008 Jun 6;73(11):4155-9. doi: 10.1021/jo800454w. Epub 2008 May 8.
PMID:18462003
Abstract
Bis-18,18'-desmethyl ritterazine N has been prepared in enantiomerically pure form. The synthetic alkaloid, lacking only two of the 52 carbon atoms of the natural product, shows selective activity in the NIH 60 cell panel.
摘要
双-18,18'-去甲基瑞他嗪N已被制备成对映体纯的形式。这种合成生物碱仅缺少天然产物52个碳原子中的两个，在NIH 60细胞板中显示出选择性活性。
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