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[人类基因组计划:基因组医学的联合项目]

[Human genome project: a federator program of genomic medicine].

作者信息

Sfar S, Chouchane L

机构信息

Laboratoire d'immuno-oncologie moléculaire, faculté de médecine de Monastir, avenue Avicenne, Monastir, Tunisia.

出版信息

Pathol Biol (Paris). 2008 May;56(3):170-5. doi: 10.1016/j.patbio.2007.12.001. Epub 2008 Mar 5.

Abstract

The Human Genome Project improves our understanding of the molecular genetics basis of the inherited and complex diseases such as diabetes, schizophrenia, and cancer. Information from the human genome sequence is essential for several antenatal and neonatal screening programmes. The new genomic tools emerging from this project have revolutionized biology and medicine and have transformed our understanding of health and the provision of healthcare. Its implications pervade all areas of medicine, from disease prediction and prevention to the diagnosis and treatment of all forms of disease. Increasingly, it will be possible to drive predisposition testing into clinical practice, to develop new treatments or to adapt available treatments more specifically to an individual's genetic make-up. This genomic information should transform the traditional medications that are effective for every members of the population to personalized medicine and personalized therapy. The pharmacogenomics could give rise to a new generation of highly effective drugs that treat causes, not just symptoms.

摘要

人类基因组计划增进了我们对诸如糖尿病、精神分裂症和癌症等遗传性和复杂性疾病的分子遗传学基础的理解。人类基因组序列信息对于多个产前和新生儿筛查项目至关重要。该项目所产生的新基因组工具彻底改变了生物学和医学,并改变了我们对健康和医疗保健提供的理解。其影响遍及医学的各个领域,从疾病预测和预防到各种疾病的诊断和治疗。越来越有可能将易感性检测应用于临床实践,开发新的治疗方法或使现有治疗方法更具体地适应个体的基因构成。这种基因组信息应将对人群中每个成员都有效的传统药物转变为个性化医学和个性化治疗。药物基因组学可能会催生新一代不仅治疗症状,而且治疗病因的高效药物。

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