Di Trapani G, Fioravanti M
Clinica Neurologica, Università Cattolica del Sacro Cuore di Roma.
Clin Ter. 1991 Jun 30;137(6):403-13.
A three months study was performed on 150 aging patients with primary memory deficits in order to verify the effectiveness of CDP-Choline, administered in repeated cycles of four weeks, with an interval of one week between cycles, in improving patients' cognitive and behavioral efficiency and in stabilizing their cognitive decline. Objective measures of memory and attention, and a behavioral rating scale were used to assess treatment effects. CDP-Choline treatment demonstrated both symptomatic efficacy and a long lasting effect on cognition and behavior of these patients. Level of activation and attention responsiveness improved during treatment cycles and no further changes were identified of these variables in the follow-up period. Measures related to specific memory functioning showed, besides improvements during treatment, after-effects still active in the follow-up period, suggesting a long lasting change of the cognitive decline trend characteristic of these patients.
对150名患有原发性记忆缺陷的老年患者进行了为期三个月的研究，以验证胞磷胆碱的有效性。胞磷胆碱以四周为一个重复周期给药，周期之间间隔一周，旨在提高患者的认知和行为效率，并稳定其认知衰退。使用记忆和注意力的客观测量方法以及行为评定量表来评估治疗效果。胞磷胆碱治疗对这些患者的症状具有疗效，并且对认知和行为具有持久影响。在治疗周期中，激活水平和注意力反应性有所改善，在随访期间未发现这些变量有进一步变化。与特定记忆功能相关的测量结果显示，除了在治疗期间有所改善外，在随访期间仍有后续效应，这表明这些患者认知衰退趋势发生了持久变化。
