Serra F, Diaspri G P, Gasbarrini A, Giancane S, Rimondi A, Tamè M R, Sakellaridis E, Bernardi M, Gasbarrini G
Scuola di Specializzazione in Geriatria e Gerontologia, 1a Cattedra di Patologia Speciale Medica e Metodologia Clinica, Università degli Studi di Bologna.
Minerva Med. 1990 Jun;81(6):465-70.
The efficacy of CDP-choline (1000 mg/die) administered for two 21-day treatment cycles, with a one-week wash-out period between them, was evaluated in out and in-patients suffering from mild to moderate brain aging. The study was performed on 237 fully evaluable patients with the use of the reduced geriatric scale of Plutchik and al., for clinical evaluation of the symptomatology. The clinical data obtained demonstrate that treatment with CDP-choline is able to determine an improvement of symptomatology since the 1st cycle of therapy (p less than 0.001), and a further improvement in the 2nd cycle (p less than 0.001). Particularly, the therapeutic effect of the 1st cycle is persistent in the intermediate wash-out period (suspension of treatment) with a further decrease, of symptomatology regarding some items of Plutchik's scale (p less than 0.01). Finally, treatment with CDP-choline 1000 mg/die for two 21-day cycles in 237 patients suffering from brain aging determined a statistically significant improvement of the cognitive and behavioural parameters taken into consideration: independence/autonomous life; human relations/social life; interest and attentive capacity; individual behaviour. Therefore citicoline is confirmed as a valid therapeutic remedy for the clinical, functional and social recovery of these patients.
对患有轻度至中度脑老化的门诊和住院患者，评估了连续两个21天治疗周期（中间有一周洗脱期）给予胞磷胆碱（1000毫克/日）的疗效。该研究对237名完全可评估的患者进行，使用Plutchik等人简化的老年量表对症状进行临床评估。获得的临床数据表明，从治疗的第1周期开始，胞磷胆碱治疗就能改善症状（p<0.001），在第2周期进一步改善（p<0.001）。特别是，第1周期的治疗效果在中间洗脱期（治疗中断）持续存在，Plutchik量表某些项目的症状进一步减轻（p<0.01）。最后，在237名脑老化患者中，给予1000毫克/日胞磷胆碱进行两个21天周期的治疗，所考虑的认知和行为参数有统计学显著改善：独立/自主生活；人际关系/社会生活；兴趣和注意力；个人行为。因此，胞磷胆碱被确认为这些患者临床、功能和社会康复的有效治疗药物。
