Bink Karin, Haralambieva Eugenia, Kremer Marcus, Ott German, Beham-Schmid Christine, de Leval Laurence, Peh Suat Cheng, Laeng Hubert R, Jütting Uta, Hutzler Peter, Quintanilla-Martinez Leticia, Fend Falko
Institutes of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Oberschleissheim, Germany.
Haematologica. 2008 Apr;93(4):623-6. doi: 10.3324/haematol.12005. Epub 2008 Mar 6.
Primary extramedullary plasmacytoma is an indolent neoplasm that infrequently converts to multiple myeloma. Since cytogenetic data on extramedullary plasmacytoma are lacking, we studied 38 cases of this type of neoplasm by fluorescence in situ hybridization. Fourteen cases (37%) contained IGH breaks, including six with a t(4;14) translocation. No translocations t(11;14), t(14;16), t(8;14), nor breaks involving MALT1, BCL6 or FOXP1 were found. Loss of 13q (40%), as well as chromosomal gains (82%) were common. There was no correlation between chromosomal alterations and clinical features or local relapse. Cytogenetically, extramedullary plasmacytoma and multiple myeloma are closely related. However, the distribution of IGH translocation partners, with the notable absence of t(11;14), is different. Key words: extramedullary plasmacytoma, multiple myeloma, cytogenetics, IGH translocation, fluorescence in situ hybridization.
原发性髓外浆细胞瘤是一种惰性肿瘤，很少转化为多发性骨髓瘤。由于缺乏髓外浆细胞瘤的细胞遗传学数据，我们通过荧光原位杂交研究了38例此类肿瘤。14例（37%）存在IGH断裂，其中6例有t(4;14)易位。未发现t(11;14)、t(14;16)、t(8;14)易位，也未发现涉及MALT1、BCL6或FOXP1的断裂。13q缺失（40%）以及染色体增加（82%）很常见。染色体改变与临床特征或局部复发之间无相关性。在细胞遗传学上，髓外浆细胞瘤与多发性骨髓瘤密切相关。然而，IGH易位伙伴的分布不同，明显不存在t(11;14)。关键词：髓外浆细胞瘤；多发性骨髓瘤；细胞遗传学；IGH易位；荧光原位杂交
