Gilbert Clare E, Ellwein Leon B
International Centre for Eye Health, Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Invest Ophthalmol Vis Sci. 2008 Mar;49(3):877-81. doi: 10.1167/iovs.07-0973.
Data on the prevalence and causes of functional low vision (FLV) in adults and children are lacking but are important for planning low-vision services. This study was conducted to determine the prevalence and causes of FLV among children recruited in eight population-based prevalence surveys of visual impairment and refractive error from six countries (India [2 locations]; China [2 locations]; Malaysia, Chile, Nepal, and South Africa).
Using the same protocol, 4082 to 6527 children aged 5 (or 7) to 15 years were examined at each site. Uncorrected and presenting visual acuities were successfully measured with retroilluminated logMAR tumbling-E charts in 3997 to 5949 children; cycloplegic autorefraction was performed and best corrected acuities assessed. All children were examined by an ophthalmologist and a cause of visual loss assigned to eyes with uncorrected acuity < or =6/12. The prevalence of FLV was determined overall and by site; associations with gender, age, parental education and urban/rural location were assessed with logistic regression.
The prevalence of FLV ranged from 0.65 to 2.75 in 1000 children, with wide confidence intervals. The overall prevalence was 1.52 in 1000 children (95% CI 1.16-1.95). FLV was significantly associated with age (odds ratio [OR] 1.13 for each year, P = 0.01), and parental education was protective (OR 0.75 for each of five levels of education, P = 0.017). Retinal lesions and amblyopia were the commonest causes.
More studies are needed to determine the prevalence and causes of FLV in children so that services can be planned that promote independence, improve quality of life, and increase access to education.
目前缺乏关于成人和儿童功能性低视力(FLV)患病率及病因的数据,但这些数据对于规划低视力服务很重要。本研究旨在确定在来自六个国家(印度[2个地点];中国[2个地点];马来西亚、智利、尼泊尔和南非)的八项基于人群的视力损害和屈光不正患病率调查中招募的儿童中FLV的患病率及病因。
各研究地点均采用相同方案,对4082至6527名5(或7)至15岁儿童进行检查。在3997至5949名儿童中,使用视网膜反光对数视力表(logMAR)翻转E字视力表成功测量了未矫正视力和就诊视力;进行了睫状肌麻痹验光并评估了最佳矫正视力。所有儿童均由眼科医生进行检查,并为未矫正视力≤6/12的眼睛确定视力丧失的原因。总体及各研究地点分别确定了FLV的患病率;采用逻辑回归评估其与性别、年龄、父母教育程度和城乡居住地的关联。
每1000名儿童中FLV的患病率在0.65至2.75之间,置信区间较宽。总体患病率为每1000名儿童中有1.52例(95%可信区间1.16 - 1.95)。FLV与年龄显著相关(每年的比值比[OR]为1.13,P = 0.01),父母教育程度具有保护作用(五个教育水平中每个水平的OR为0.75,P = 0.017)。视网膜病变和弱视是最常见的病因。
需要开展更多研究以确定儿童FLV的患病率及病因,从而规划能够促进独立性、改善生活质量并增加受教育机会的服务。