Wang Yan, Dong Lei, Zou Bai-cang, Li Hui-peng
Department of Gastroenterology, Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Feb;33(2):93-8.
To explore the effect of ghrelin on the duodenal myoelectrical activity during the feeding state and the fasting state in rats.
One pair of bipolar silver electrodes were chronically implanted in the duodenal serosa of rats for electromyography. The myoelectrical activity was recorded when ghrelin was injected intravenously into rats during the feeding state or the fasting state. Some rats were pretreated with atropine, phentolamine, propranolol, L-arginine, and (D-Lys3)GHRP-6 respectively to explore the mechanism of ghrelin.
Duodenal migrating myoelectrical complex (MMC) could be induced by ghrelin in the feeding state. Ghrelin could shorten the length of duodenal MMC cycle and increase the amplitude and frequency of phase III during the fasting state. The percentage of phase III in the MMC cycle did not change. These effects were inhibited by atropine and L-arginine (D-Lys3)GHRP-6, but not by propranolol and phentolamine.
Ghrelin seems to be closely related to the duodenal motility. The excitatory effect of ghrelin on duodenal MMC might rely on the cholinergic pathway, and have a close relationship with NO. The receptor of ghrelin can regulate its activity.
探讨胃饥饿素对大鼠进食状态和禁食状态下十二指肠肌电活动的影响。
将一对双极银电极长期植入大鼠十二指肠浆膜用于肌电图检查。在进食状态或禁食状态下给大鼠静脉注射胃饥饿素时记录肌电活动。分别用阿托品、酚妥拉明、普萘洛尔、L-精氨酸和（D-Lys3）GHRP-6对部分大鼠进行预处理以探讨胃饥饿素的作用机制。
胃饥饿素在进食状态下可诱导十二指肠移行性肌电复合波（MMC）。胃饥饿素在禁食状态下可缩短十二指肠MMC周期长度，增加Ⅲ期的幅度和频率。MMC周期中Ⅲ期的百分比未改变。这些作用被阿托品和L-精氨酸（D-Lys3）GHRP-6抑制，但未被普萘洛尔和酚妥拉明抑制。
胃饥饿素似乎与十二指肠运动密切相关。胃饥饿素对十二指肠MMC的兴奋作用可能依赖于胆碱能途径，且与一氧化氮密切相关。胃饥饿素受体可调节其活性。
