Wang Yan, Dong Lei, Zhao Ping, Cheng Yan, Li Hui-peng
Department of Gastroenterology, Second Hospital Affiliated to Xi'an Jiaotong University College of Medicine, Xi'an 710004, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):328-32.
To investigate the effects of ghrelin on small intestinal transit and intergigestive gastrointestinal migrating myoelectric complex (MMC) in rats.
After a 24-hour fasting, the rats with or without pretreatment with receptor antagonist (D-Lys3)GHRP-6 were given intravenous injections of ghrelin at different doses to observe the changes in small intestinal transit. The MMCs of the fasting rats were recorded using a multilead physiological recording system, and their changes observed in response to intravenous ghrelin injections, or to ghrelin injection following pretreatment with atropine, phentolamine, propranolol, L-arginine or (D-Lys3)GHRP-6, respectively.
Ghrelin enhanced the small intestinal transit dose-dependently, and this effect was inhibited by application of ghrelin receptor antagonist. Ghrelin also showed excitatory effect on the MMCs, which was inhibited by atropine, L-arginine or (D-Lys3)GHRP-6, but not by propranolol and phentolamine.
Ghrelin can promote gastrointestinal motilities, and its excitatory effects rely on the cholinergic pathway in close relation to nitric oxide pathway. Ghrelin receptor is involved in its action in promoting the gastrointestinal motilities.
研究胃饥饿素对大鼠小肠转运及消化间期胃肠移行性复合运动（MMC）的影响。
禁食24小时后，对预先给予或未给予受体拮抗剂（D - Lys3）GHRP - 6的大鼠静脉注射不同剂量的胃饥饿素，观察小肠转运的变化。使用多导联生理记录系统记录禁食大鼠的MMC，并分别观察静脉注射胃饥饿素后，或在预先用阿托品、酚妥拉明、普萘洛尔、L - 精氨酸或（D - Lys3）GHRP - 6预处理后注射胃饥饿素时MMC的变化。
胃饥饿素剂量依赖性地增强小肠转运，且该作用被胃饥饿素受体拮抗剂抑制。胃饥饿素对MMC也有兴奋作用，该作用被阿托品、L - 精氨酸或（D - Lys3）GHRP - 6抑制，但不受普萘洛尔和酚妥拉明抑制。
胃饥饿素可促进胃肠运动，其兴奋作用依赖于与一氧化氮途径密切相关的胆碱能途径。胃饥饿素受体参与其促进胃肠运动的作用。
