氮杂环卡宾催化的β-内酰胺合成
N-Heterocyclic carbene catalysed beta-lactam synthesis.
作者信息
Duguet Nicolas, Campbell Craig D, Slawin Alexandra M Z, Smith Andrew D
机构信息
EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St. Andrews, UK.
出版信息
Org Biomol Chem. 2008 Mar 21;6(6):1108-13. doi: 10.1039/b800857b. Epub 2008 Feb 12.
DOI:10.1039/b800857b
PMID:18327339
Abstract
N-Heterocyclic carbenes promote the formal [2+2] cycloaddition of ketenes with N-tosyl imines to give the corresponding beta-lactams in good to excellent isolated yields; chiral NHCs give beta-lactams in high e.e. after crystallisation.
摘要
N-杂环卡宾促进了烯酮与N-甲苯磺酰亚胺的形式上的[2+2]环加成反应，以良好至优异的分离产率得到相应的β-内酰胺；手性N-杂环卡宾在结晶后能以高对映体过量得到β-内酰胺。
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