von Müller Lutz, Mertens Thomas
Department of Virology, University Hospital Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Med Microbiol Immunol. 2008 Jun;197(2):75-82. doi: 10.1007/s00430-008-0087-0. Epub 2008 Mar 8.
The human cytomegalovirus (HCMV) is a relevant pathogen in patients with immunosuppressive therapy; however, reactivation and subsequent recurrence occurs also in individuals without canonical immunosuppression as e.g., in patients with septic shock. Analyzing the impact of NK- and T-cell immunity on the natural course of HCMV infection in patients with septic shock, it became clear that the presence of HCMV reactive T-helper cells did not prevent the development of reactivation but, the control of active infection was achieved mostly by specific T-cells. NK-cells seemed to be dispensable for clearance of active infection in this patient group with long-lasting NK-cell anergy.
人巨细胞病毒（HCMV）是接受免疫抑制治疗患者的一种相关病原体；然而，在没有典型免疫抑制的个体中，如感染性休克患者，也会发生病毒再激活及随后的复发。分析自然杀伤细胞（NK细胞）和T细胞免疫对感染性休克患者HCMV感染自然病程的影响后发现，HCMV反应性辅助性T细胞的存在并不能预防再激活的发生，而对活动性感染的控制主要是通过特异性T细胞实现的。在这群存在持久NK细胞无反应性的患者中，NK细胞似乎对清除活动性感染并无必要。
