Tiefenbacher Konrad, Mulzer Johann
Institut für Organische Chemie, Universität Wien, Währingerstrasse 38, 1090 Vienna, Austria.
Angew Chem Int Ed Engl. 2008;47(14):2548-55. doi: 10.1002/anie.200705303.
In modern drug discovery, antibodies or libraries of simple synthetic organic compounds, mostly of heterocyclic origin, are favored. Natural products play an increasingly inferior role as they are considered structurally too complex, limited in quantity, and difficult to synthesize, manipulate, and derivatize. Thus it was a sensation when a Merck research group reported that classical screening of metabolites from Streptomyces platensis has unearthed a low-molecular-weight organic compound with remarkable antibiotic properties.
在现代药物研发中，抗体或简单合成有机化合物库（大多源自杂环化合物）更受青睐。天然产物的作用日益式微，因为它们被认为结构过于复杂、数量有限，且难以合成、操作和衍生化。因此，当默克研究小组报告称，对来自浅青紫链霉菌代谢产物的经典筛选发现了一种具有显著抗生素特性的低分子量有机化合物时，引起了轰动。
